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科研机构
上海药物研究所 [7]
湖南大学 [3]
大连理工大学 [1]
大连化学物理研究所 [1]
武汉大学 [1]
上海中医药大学 [1]
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内容类型
期刊论文 [14]
发表日期
2019 [6]
2018 [1]
2012 [2]
2010 [3]
2008 [2]
学科主题
Oncology [1]
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Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 137
作者:
Song, Yun-Qing
;
Guan, Xiao-Qing
;
Weng, Zi-Miao
;
Wang, Ya-Qiao
;
Chen, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/05
Glabridin
Human carboxylesterase 2 (CES2A)
Specific inhibitor
Inhibition mechanism
Irinotecan-induced diarrhea
Discovery of a highly specific and efficacious inhibitor of human carboxylesterase 2 by large-scale screening
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2019, 卷号: 137, 页码: 261-269
作者:
Song, Yun-Qing
;
Guan, Xiao-Qing
;
Weng, Zi-Miao
;
Wang, Ya-Qiao
;
Chen, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/02
Glabridin
Human carboxylesterase 2 (CES2A)
Specific inhibitor
Inhibition mechanism
Irinotecan-induced diarrhea
Herbal Medicines for Irinotecan-Induced Diarrhea
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10
作者:
Tang, Liu
;
Li, Xiaolei
;
Wan, Liping
;
Xiao, Yao
;
Zeng, Xin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
chemotherapy-induced diarrhea
irinotecan
herbal formulations
phytochemicals
mini-review
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan
期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: Vol.9 No.1, 页码: 157-166
作者:
Gao, Yiqiao
;
Li, Wei
;
Chen, Jiaqing
;
Wang, Xu
;
Lv, Yingtong
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/17
Irinotecan
Individual differences
Complicating toxicity
Prediction
Metabolomics
Gastrointestinal toxicity
Biomarkers
Diarrhea
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan
期刊论文
Acta Pharmaceutica Sinica B, 2019, 卷号: Vol.9 No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/17
Irinotecan
Individual
differences
Complicating
toxicity
Prediction
Metabolomics
Gastrointestinal
toxicity
Biomarkers
Diarrhea
Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
期刊论文
Acta pharmaceutica Sinica. B, 2019, 卷号: No.1, 页码: 157-166
作者:
Yiqiao Gao
;
Wei Li
;
Jiaqing Chen
;
Xu Wang
;
Yingtong Lv
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/12/17
AUC-ROC,
area
under
receiver
operating
characteristic
BHB,
β-hydroxybutyric
acid
Biomarkers
C,
control
group
CA,
cholic
acid
CPT-11,
irinotecan
Complicating
toxicity
DBIL,
direct
bilirubin
DCA,
deoxycholic
acid
Diarrhea
FDR,
false
discovery
rate
GCA,
glycocholic
acid
Gastrointestinal
toxicity
IBIL,
indirect
bilirubin
IT-TOF/MS,
ion
trap/time-offlight
hybrid
mass
spectrometry
Individual
differences
Irinotecan
Lys,
lysine
MSTFA,
N-methyl-N-trifluoroacetamide
Metabolomics
NS,
non-sensitive
group
NSgt,
non-sensitive
for
gastrointestinal
toxicity
NSmt,
non-sensitive
for
myelosuppression
toxicity
OPLS-DA,
orthogonal
partial
least-squares-discriminant
analysis
PCA,
principal
component
analysis
PLS-DA,
partial
least-squares-discriminant
analysis
Phe,
phenylalanine
Prediction
QC,
quality
control
RSD,
relative
standard
deviation
S,
sensitive
group
Sgt,
sensitive
for
gastrointestinal
toxicity
Smt,
sensitive
for
myelosuppression
toxicity
T,
CPT-11
treated
group
Trp,
tryptophan
UFLC,
ultrafast
liquid
chromatography
VIP,
variable
importance
in
the
projection
pFDR,
false-discovery-rate-adjusted
P
value
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 77, 页码: 320-329
作者:
Zou, Li-Wei
;
Weng, Zi-Miao
;
Ge, Guang-Bo
;
Dou, Tong-Yi
;
Wang, Ping
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/06/20
Flavonoids
Human Carboxylesterase 2 (Hce2)
Structure-inhibition Relationships
Selectivity
Inhibition Mechanism
Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity
期刊论文
Yao xue xue bao = Acta pharmaceutica Sinica, 2012, 卷号: 47, 期号: 11, 页码: 1534-40
作者:
Zhang, Xin-Xin
;
Guo, Shi-Yan
;
Li, Fei-Fei
;
Gan, Yong
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity
期刊论文
Acta Pharmaceutica Sinica, 2012, 卷号: 47, 期号: 11, 页码: 1534-1540
作者:
Zhang Xinxin
;
Guo Shiyan
;
Li Feifei
;
Gan Yong
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
PEO-PPO-PEO
irinotecan
micelle
breast cancer resistance protein
PEO-PPO-PEO
diarrhea
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