QQ客服 官方微博 反馈留言

	Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.
	Yiqiao Gao; Wei Li; Jiaqing Chen; Xu Wang; Yingtong Lv; Yin Huang; Zunjian Zhang; Fengguo Xu
刊名	Acta pharmaceutica Sinica. B
	2019
卷号	No.1页码:157-166
关键词	AUC-ROC, area under receiver operating characteristic BHB, β-hydroxybutyric acid Biomarkers C, control group CA, cholic acid CPT-11, irinotecan Complicating toxicity DBIL, direct bilirubin DCA, deoxycholic acid Diarrhea FDR, false discovery rate GCA, glycocholic acid Gastrointestinal toxicity IBIL, indirect bilirubin IT-TOF/MS, ion trap/time-offlight hybrid mass spectrometry Individual differences Irinotecan Lys, lysine MSTFA, N-methyl-N-trifluoroacetamide Metabolomics NS, non-sensitive group NSgt, non-sensitive for gastrointestinal toxicity NSmt, non-sensitive for myelosuppression toxicity OPLS-DA, orthogonal partial least-squares-discriminant analysis PCA, principal component analysis PLS-DA, partial least-squares-discriminant analysis Phe, phenylalanine Prediction QC, quality control RSD, relative standard deviation S, sensitive group Sgt, sensitive for gastrointestinal toxicity Smt, sensitive for myelosuppression toxicity T, CPT-11 treated group Trp, tryptophan UFLC, ultrafast liquid chromatography VIP, variable importance in the projection pFDR, false-discovery-rate-adjusted P value
ISSN号	2211-3835
URL标识	查看原文
公开日期	[db:dc_date_available]
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/4740197
专题	湖南大学
作者单位	Key Laboratory of Drug Quality Control and Pharmacovigilance , State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, China. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China.
推荐引用方式 GB/T 7714	Yiqiao Gao,Wei Li,Jiaqing Chen,et al. Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.[J]. Acta pharmaceutica Sinica. B,2019,No.1:157-166.
APA	Yiqiao Gao.,Wei Li.,Jiaqing Chen.,Xu Wang.,Yingtong Lv.,...&Fengguo Xu.(2019).Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan..Acta pharmaceutica Sinica. B,No.1,157-166.
MLA	Yiqiao Gao,et al."Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan.".Acta pharmaceutica Sinica. B No.1(2019):157-166.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。