Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity
	Zhang, Xin-Xin; Guo, Shi-Yan; Li, Fei-Fei; Gan, Yong
刊名	Yao xue xue bao = Acta pharmaceutica Sinica
	2012-11
卷号	47 期号:11 页码:1534-40
ISSN号	0513-4870
文献子类	Article
英文摘要	In this work, we developed PEO-PPO-PEO micelles loaded with irinotecan hydrochloride (CPT-11) using breast cancer resistance protein (BCRP) inhibitory material PEO20-PPO70-PEO20, and studied its mechanism of decreasing CPT-11 induced delayed diarrhea and intestinal toxicity. BCRP-overexpressing MDCKII (MDCKII/BCRP) cells were used to evaluate the effect of PEO20-PPO70-PEO20 and PEO-PPO-PEO micelles on transmembrane transport of CPT-11 in vitro. The biliary excretion, delayed diarrhea and intestinal damage of CPT-11 loaded PEO-PPO-PEO micelles of rats were investigated. The results showed that the obtained micelles could decrease the biliary excretion of CPT-11, ameliorate delayed diarrhea and intestinal toxicity of rats through inhibiting BCRP-mediated CPT-11 efflux. PEO-PPO-PEO micelles were promising carriers to reduce intestinal toxicity of CPTs.
语种	中文
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/266283]
专题	药物制剂研究中心
作者单位	Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
推荐引用方式 GB/T 7714	Zhang, Xin-Xin,Guo, Shi-Yan,Li, Fei-Fei,et al. Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity[J]. Yao xue xue bao = Acta pharmaceutica Sinica,2012,47(11):1534-40.
APA	Zhang, Xin-Xin,Guo, Shi-Yan,Li, Fei-Fei,&Gan, Yong.(2012).Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity.Yao xue xue bao = Acta pharmaceutica Sinica,47(11),1534-40.
MLA	Zhang, Xin-Xin,et al."Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity".Yao xue xue bao = Acta pharmaceutica Sinica 47.11(2012):1534-40.