Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药物制剂研究中心

	Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity
	Zhang Xinxin; Guo Shiyan; Li Feifei; Gan Yong
刊名	Acta Pharmaceutica Sinica
	2012
卷号	47 期号:11 页码:1534-1540
关键词	PEO-PPO-PEO irinotecan micelle breast cancer resistance protein PEO-PPO-PEO diarrhea
ISSN号	0513-4870
其他题名	伊立替康PEO-PPO-PEO胶束的制备和表征及其降低药物消化道毒性的机制研究
文献子类	Article
英文摘要	In this work, we developed PEO-PPO-PEO micelles loaded with irinotecan hydrochloride (CPT-11) using breast cancer resistance protein (BCRP) inhibitory material PEO_(20)-PPO_(70)-PEO_(20), and studied its mechanism of decreasing CPT-11 induced delayed diarrhea and intestinal toxicity. BCRP-overexpressing MDCKII (MDCKII/BCRP) cells were used to evaluate the effect of PEO_(20)-PPO_(70)-PEO_(20) and PEO-PPO-PEO micelles on transmembrane transport of CPT-11 in vitro. The biliary excretion, delayed diarrhea and intestinal damage of CPT-11 loaded PEO-PPO-PEO micelles of rats were investigated. The results showed that the obtained micelles could decrease the biliary excretion of CPT-11, ameliorate delayed diarrhea and intestinal toxicity of rats through inhibiting BCRP-mediated CPT-11 efflux. PEO-PPO-PEO micelles were promising carriers to reduce intestinal toxicity of CPTs.
资助项目	国家自然科学基金资助项目[00000000] ; 河北省自然科学基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4665972
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267817]
专题	药物制剂研究中心
通讯作者	Gan Yong
作者单位	Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Zhang Xinxin,Guo Shiyan,Li Feifei,et al. Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity[J]. Acta Pharmaceutica Sinica,2012,47(11):1534-1540.
APA	Zhang Xinxin,Guo Shiyan,Li Feifei,&Gan Yong.(2012).Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity.Acta Pharmaceutica Sinica,47(11),1534-1540.
MLA	Zhang Xinxin,et al."Preparation and characterization of irinotecan hydrochloride loaded PEO-PPO-PEO micelles and its mechanism of decreasing drug intestinal toxicity".Acta Pharmaceutica Sinica 47.11(2012):1534-1540.