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复旦大学上海医学院 [10]
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上海中医药大学 [3]
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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:
Li, Cai
;
Zhang, Yifan
;
Chen, Weili
;
Lu, Youming
;
Li, Wei
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
P2Y(12) inhibitor
Pharmacokinetics
Active metabolite
Thienopyridine
Chinese patients carrying two CYP2C19 LOFs have a more active state of P2Y(12)-G(i) signaling and larger MPV in post-clopidogrel platelets with acute coronary syndrome
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 卷号: 12, 期号: 7
作者:
Xu, Huajie
;
Wu, Hongyi
;
Zhao, Xin
;
Zhang, Yan
;
Chen, She
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/12/05
CYP2C19
clopidogrel
P2Y(12)
VASP
Akt
MPV
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127
作者:
Liu, Cai
;
Zhang, Yifan
;
Chen, Weili
;
Lu, Youming
;
Li, Wei
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/05
Vicagrel
Clopidogrel
P2Y(12) inhibitor
Pharmacokinetics
Active metabolite
Thienopyridine
P2Y(12) deficiency in mouse impairs noradrenergic system in brain, and alters anxiety-like neurobehavior and memory
期刊论文
GENES BRAIN AND BEHAVIOR, 2019, 卷号: 18, 期号: 2
作者:
Zheng, F.
;
Zhou, Q.
;
Cao, Y.
;
Shi, H.
;
Wu, H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
anxiety
locomotion
memory
noradrenaline
P2Y(12)
Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 149, 页码: 394-402
作者:
Liu, Cai
;
Lu, Youming
;
Sun, Hongbin
;
Yang, Jin
;
Liu, Yongqiang
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
Active metabolite
LC-MS/MS
Human plasma
P2Y(12) inhibitor
Preparation and characterization of solid dispersion of novel dual antiplatelet agent BF061 for oral use
期刊论文
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2018, 卷号: 43
作者:
Chen, Leilei
;
Han, Limei
;
Hu, Liang
;
Liang, Jianying
;
Wang, Jianxin
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Antiplatelet agent
P2Y(12)
Solid dispersion
BF061
Platelets Express Activated P2Y(12) Receptor in Patients With Diabetes Mellitus
期刊论文
CIRCULATION, 2017, 卷号: 136, 期号: 9, 页码: 817-U102
作者:
Hu, Liang
;
Chang, Lin
;
Zhang, Yan
;
Zhai, Lili
;
Zhang, Shenghui
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
antiplatelet
antithrombotic
AR-C78511
cangrelor
inverse agonist
P2Y(12)
P2Y(12) receptor antagonist
type 2 diabetes mellitus
Role of P2Y(12) Receptor in Thrombosis
期刊论文
THROMBOSIS AND EMBOLISM: FROM RESEARCH TO CLINICAL PRACTICE, VOL 1, 2017, 卷号: 906
作者:
Zhang, Yaqi
;
Zhang, Si
;
Ding, Zhongren
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Platelet
P2Y(12) receptor
Signal transductions
Abnormalities
Antagonists
P2Y(12) receptor gene polymorphism and the risk of resistance to clopidogrel: A meta-analysis and review of the literature
期刊论文
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 卷号: 26, 期号: 2
作者:
Cui, Guozhen
;
Zhang, Shaoyan
;
Zou, Jia
;
Chen, Yang
;
Chen, Hao
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
polymorphism
cardiovascular diseases
resistance
clopidogrel
P2Y(12)
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