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The discovery of a novel series of potential ERR alpha inverse agonists based on p-nitrobenzenesulfonamide template for triple-negative breast cancer in vivo 期刊论文
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2022, 卷号: 37, 期号: 1, 页码: 125-134
作者:  Gao, Zhipei;  Wang, Tianxiao;  Li, Rui;  Du, Yongli;  Lv, Han
收藏  |  浏览/下载:37/0  |  提交时间:2022/01/18
Molecular Dynamics Simulations Based on 1-Phenyl-4-Benzoyl-1-Hydro-Triazole ERR alpha Inverse Agonists 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 卷号: 22, 期号: 7, 页码: 14
作者:  Gao, Zhipei;  Du, Yongli;  Sheng, Xiehuang;  Shen, Jingkang
收藏  |  浏览/下载:25/0  |  提交时间:2021/05/24
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:  Yu, Ming-cheng;  Yang, Feng;  Ding, Xiao-yu;  Sun, Nan-nan;  Jiang, Zheng-yuan
收藏  |  浏览/下载:82/0  |  提交时间:2020/12/24
Cryo-EM Structure of the Human Cannabinoid Receptor CB2-G(i) Signaling Complex 期刊论文
CELL, 2020, 卷号: 180, 期号: 4, 页码: 645-+
作者:  Xing, Changrui;  Zhuang, Youwen;  Xu, Ting-Hai;  Feng, Zhiwei;  Zhou, X. Edward
收藏  |  浏览/下载:51/0  |  提交时间:2020/07/01
A molecular switch regulating transcriptional repression and activation of PPAR gamma 期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 14
作者:  Shang, Jinsai;  Mosure, Sarah A.;  Zheng, Jie;  Brust, Richard;  Bass, Jared
收藏  |  浏览/下载:21/0  |  提交时间:2020/12/24
Designing of novel ERR gamma inverse agonists by molecular modeling studies of docking and 3D-QSAR on hydroxytamoxifen derivatives 期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2019, 卷号: 28, 期号: 10, 页码: 1661-1673
作者:  Li, Rui;  Du, Yongli;  Shen, Jingkang
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/01
Cannabinoid CB1 receptor neutral antagonist AM4113 inhibits heroin self-administration without depressive side effects in rats 期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 3
作者:  He, Xiang-hu;  Jordan, Chloe J.;  Vemuri, Kiran;  Bi, Guo-hua;  Zhan, Jia
收藏  |  浏览/下载:16/0  |  提交时间:2019/12/05
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist? 期刊论文
CELL DEATH & DISEASE, 2019, 卷号: 10
作者:  Wu, Guangzhen;  Wang, Qinglian;  Xu, Yingkun;  Li, Jianyi;  Zhang, Hongge
收藏  |  浏览/下载:3/0  |  提交时间:2019/12/11
A Drug with Lipophilicity-Dependent Potency Can Be Metabolically Stable: Discovery of a Potent and Selective Retinoic Acid Receptor-Related Orphan Receptor C2 (RORC2) Inverse Agonist as an Orally Bioavailable Anti-Inflammatory Agent 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 23, 页码: 10412-10414
作者:  Wang, Yibing;  Liu, Hong
收藏  |  浏览/下载:78/0  |  提交时间:2019/01/08
Structural basis for signal recognition and transduction by platelet-activating-factor receptor 期刊论文
NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 卷号: 25, 期号: 6, 页码: 488-+
作者:  Cao, Can;  Tan, Qiuxiang;  Xu, Chanjuan;  He, Lingli;  Yang, Linlin
收藏  |  浏览/下载:68/0  |  提交时间:2019/01/08


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