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上海药物研究所 [17]
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期刊论文 [30]
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Synthesis and Evaluation of 3-(Indol-3-yl)-4-(Pyrazolo[3,4-c]Pyridazin-3-yl)-Maleimides as Potent Mutant Isocitrate Dehydrogenase-1 Inhibitors
期刊论文
PHARMACEUTICAL CHEMISTRY JOURNAL, 2021, 卷号: 55, 期号: 7, 页码: 655-664
作者:
Xu, Jianghong
;
Hu, Yuanyuan
;
Liu, Xiaoqi
;
Gao, Anhui
;
Gao, Lixin
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2021/12/01
IDH1-R132H inhibitors
synthesis
biological activity
docking
3-(indol-3-yl)-4-(pyrazolo-[3
4-c]pyridazin-3-yl)-maleimides
Inhibition of B-cell receptor signaling disrupts cell adhesion in mantle cell lymphoma via RAC2
期刊论文
BLOOD ADVANCES, 2021, 卷号: 5, 期号: 1, 页码: 185-197
作者:
Wu, Wenjun
;
Wang, Weige
;
Franzen, Carrie A.
;
Guo, Hui
;
Lee, Jimmy
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Method for obtaining junction temperature of power semiconductor devices combining computational fluid dynamics and thermal network
期刊论文
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2020, 卷号: 976, 页码: 10
作者:
Peng, Lisha
;
Shen, Wanzeng
;
Feng, Anhui
;
Liu, Yan
;
Gao, Daqing
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/12/09
IGBT module
Junction temperature
Thermal network
CFD simulation
Cold plate
Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
期刊论文
DIABETES, 2019, 卷号: 68, 期号: 12, 页码: 2197-2209
作者:
Jiang, Haowen
;
Jin, Jia
;
Duan, Yanan
;
Xie, Zhifu
;
Li, Yufeng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 页码: 9
作者:
Li, Yiming
;
Rizvi, S. Aal-e-Ali
;
Hu, Deqing
;
Sun, Danwen
;
Gao, Anhui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
oxygen
oxygenation
photocatalysis
sulfides
uranyl catalysis
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:
Tong, Lexian
;
Song, Pinrao
;
Jiang, Kailong
;
Xu, Lei
;
Jin, Tingting
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
CHK1 kinase inhibitor
Selectivity
Monotherapy
Hematologic malignancies
Discovery of novel indoleaminopyrimidine NIK inhibitors based on molecular docking-based support vector regression (SVR) model
期刊论文
CHEMICAL PHYSICS LETTERS, 2019, 卷号: 718, 页码: 38-45
作者:
Ye, Qing
;
Li, Qiu
;
Gao, Anhui
;
Ying, Huazhou
;
Cheng, Gang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 4, 页码: 589-603
作者:
Liu, Xiaoqi
;
Hu, Yuanyuan
;
Gao, Anhui
;
Xu, Meng
;
Gao, Lixin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
3-Aryl-4-indolyl-maleimides
IDH1/R132H inhibitors
Tumor 2-HG
Synthesis
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