CORC

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CORC

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Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090
作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan
收藏  |  浏览/下载：22/0  |  提交时间：2022/01/04
Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文
CHEMMEDCHEM, 2021, 页码: 12
作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao
收藏  |  浏览/下载：133/0  |  提交时间：2021/05/24
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:  Gao, Yang;  Wen, Pengbo;  Chen, Bin;  Hu, Guanshuo;  Wu, Lijun
收藏  |  浏览/下载：49/0  |  提交时间：2020/11/30
Harnessing the targeting potential of differential radiobiological effects of photon versus particle radiation for cancer treatment 期刊论文
JOURNAL OF CELLULAR PHYSIOLOGY, 2020, 页码: 17
作者:  Zhang, Jinhua;  Si, Jing;  Gan, Lu;  Zhou, Rong;  Guo, Menghuan
收藏  |  浏览/下载：24/0  |  提交时间：2022/01/12
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01
Acetyl-macrocalin B suppresses tumor growth in esophageal squamous cell carcinoma and exhibits synergistic anti-cancer effects with the Chk1/2 inhibitor AZD7762 期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 卷号: 365, 页码: 71-83
作者:  Wang, Jing-Nan;  Che, Yun;  Yuan, Zu-Yang;  Lu, Zhi-Liang;  Li, Yuan
收藏  |  浏览/下载：75/0  |  提交时间：2019/03/18
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1 期刊论文
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2018, 卷号: 76, 页码: 53-60
作者:  Li, Yaping;  Peng, Jiale;  Zhou, Yeheng;  Li, Penghua;  Li, Yingying
收藏  |  浏览/下载：29/0  |  提交时间：2018/11/12
Pharmacophore modeling, molecular docking and molecular dynamics simulations toward identifying lead compounds for Chk1 期刊论文
Computational Biology and Chemistry, 2018
作者:  Yaping Li;  Jiale Peng;  Yeheng Zhou;  Penghua Li;  Yingying Li
收藏  |  浏览/下载：3/0  |  提交时间：2019/02/28
RNF126 as a biomarker of a poor prognosis in invasive breast cancer and CHK1 inhibitor efficacy in breast cancer cells 期刊论文
Clinical Cancer Research, 2018, 卷号: 24, 期号: 7, 页码: 1629-1643
作者:  Shanhuai Ma;  Pengyan Fa;  Zhefu Ma;  Hongbing Wang;  Yao Zhang
收藏  |  浏览/下载：35/0  |  提交时间：2018/09/28
The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 4
作者:  Zhou, Zhi-rui;  Yang, Zhao-zhi;  Wang, Shao-jia;  Zhang, Li;  Luo, Ju-rui
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/05

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