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浏览/检索结果: 共9条，第1-9条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 20, 页码: 15069-15090 作者:  Jin, Tingting;  Xu, Lei;  Wang, Peipei;  Hu, Xiaobei;  Zhang, Runyuan 收藏  |  浏览/下载：22/0  |  提交时间：2022/01/04 Design, Synthesis, and Biological Evaluation of Orally Bioavailable CHK1 Inhibitors Active against Acute Myeloid Leukemia 期刊论文 CHEMMEDCHEM, 2021, 页码: 12 作者:  Jin, Tingting;  Wang, Peipei;  Long, Xiubing;  Jiang, Kailong;  Song, Pinrao 收藏  |  浏览/下载：133/0  |  提交时间：2021/05/24 CHK1 inhibitor  diaminopyrimidine  DNA damage response  oral bioavailability   A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文 DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959 作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua 收藏  |  浏览/下载：35/0  |  提交时间：2021/08/17 TPN171H  PDE5 inhibitor  safety  pharmacokinetics  food effect  healthy subjects   Exploring the protective effects of Danqi Tongmai tablet on acute myocardial ischemia rats by comprehensive metabolomics profiling 期刊论文 PHYTOMEDICINE, 2020, 卷号: 74, 页码: 9 作者:  Li Zhenwei;  Hou Jinjun;  Deng Yanping;  Zhi Haijuan;  Wu Wenyong 收藏  |  浏览/下载：27/0  |  提交时间：2020/12/24 Danqi Tongmai tablet  Acute myocardial ischemia  Metabolomics  Lipidomics  Network pharmacology   Protein encapsulation: a new approach for improving the capability of small-molecule fluorogenic probes 期刊论文 CHEMICAL SCIENCE, 2020, 卷号: 11, 期号: 4, 页码: 1107-1113 作者:  Han, Hai-Hao;  Sedgwick, Adam C.;  Shang, Ying;  Li, Na;  Liu, Tingting 收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01 Selective activation of TWIK-related acid-sensitive K+ 3 subunit-containing channels is analgesic in rodent models 期刊论文 SCIENCE TRANSLATIONAL MEDICINE, 2019, 卷号: 11, 期号: 519, 页码: 12 作者:  Liao, Ping;  Qiu, Yunguang;  Mo, Yiqing;  Fu, Jie;  Song, Zhenpeng 收藏  |  浏览/下载：30/0  |  提交时间：2020/07/01 Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62 作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting 收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 CHK1 kinase inhibitor  Selectivity  Monotherapy  Hematologic malignancies   Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 128, 页码: 293-299 作者:  Wang, Jiang;  Su, Mingbo;  Li, Tingting;  Gao, Anhui;  Yang, Wei 收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08 HDAC inhibitor  Anti-proliferation  Western blot  Thienopyrimidine  Structure-activity relationship   Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 卷号: 23, 期号: 17, 页码: 5881-5890 作者:  Yang, Wei;  Li, Lixuan;  Wang, Yulan;  Wu, Xiaowei;  Li, Tingting 收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 HDACs  HDACs inhibitor  Hydroxamic acid  Isoquinoline