CORC

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CORC

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Facile and Cost-Effective Route for the Synthesis of Simmerafil 期刊论文
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2432-2437
作者:  Odilov, Abdullajon;  Liu, Yin;  Hu, Tianwen;  Jiang, Xiangrui;  Suo, Jin
收藏  |  浏览/下载：20/0  |  提交时间：2022/01/18
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua
收藏  |  浏览/下载：34/0  |  提交时间：2021/08/17
Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8
作者:  Zhang, Mengqi;  Liu, Haiming;  He, Jiajin;  Gui, Yuzhou;  Qian, Hongjie
收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei;  Xu, Ye-chun
收藏  |  浏览/下载：68/0  |  提交时间：2020/12/24
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01
Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity 期刊论文
ADVANCED SYNTHESIS & CATALYSIS, 2019, 卷号: 361, 期号: 6, 页码: 1419-1440
作者:  Qiao, Jin;  Jia, Xiuwen;  Li, Pinyi;  Liu, Xiaoyan;  Zhao, Jingwei
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/01
Green and Facile Assembly of Diverse Fused N-Heterocycles Using Gold-Catalyzed Cascade Reactions in Water 期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 5, 页码: 30
作者:  Jia, Xiuwen;  Li, Pinyi;  Liu, Xiaoyan;  Lin, Jiafu;  Chu, Yiwen
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01
Two Birds with One Stone: Regular Use of PDE5 Inhibitors for Treating Male Patients with Erectile Dysfunction and Cardiovascular Diseases 期刊论文
2019, 卷号: 33, 期号: 1, 页码: 119-128
作者:  Cai, Zhonglin;  Zhang, Jianzhong;  Li, Hongjun
收藏  |  浏览/下载：4/0  |  提交时间：2020/01/03
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:  Mao, Fei;  Wang, Huan;  Ni, Wei;  Zheng, Xinyu;  Wang, Manjiong
收藏  |  浏览/下载：56/0  |  提交时间：2019/01/08

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