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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Yu, Ming-cheng;  Yang, Feng;  Ding, Xiao-yu;  Sun, Nan-nan;  Jiang, Zheng-yuan 收藏  |  浏览/下载：85/0  |  提交时间：2020/12/24 RORγ  t  cocrystal structures  MD simulation  “  short”  inverse agonists  agonists  “  long”  inverse agonists   Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans 期刊论文 ARCHIVES OF TOXICOLOGY, 2020, 页码: 7 作者:  Ma, Jiang;  Zhang, Wei;  He, Yisheng;  Zhu, Lin;  Zhang, Chunyuan 收藏  |  浏览/下载：41/0  |  提交时间：2020/12/24 Pyrrolizidine alkaloids  Liver injury  Diagnostic biomarkers  Pyrrole-hemoglobin adducts  Pyrrole-plasma protein adducts   Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Zhu, Lin;  Zhang, Chun-yuan;  Li, Dong-ping;  Chen, Hu-biao;  Ma, Jiang 收藏  |  浏览/下载：18/0  |  提交时间：2020/12/24 herb-induced liver injury  hepatic sinusoidal obstruction syndrome  pyrrolizidine alkaloids  Tu-San-Qi  Gynura japonica   A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters 期刊论文 TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 404, 页码: 14 作者:  Wang, Ying;  Zhu, Yao;  Niu, Junxing;  Deng, Qiangqiang;  Guo, Shimeng 收藏  |  浏览/下载：60/0  |  提交时间：2020/12/21 Bile acid analog  NASH  TGR5  Cd36  AMPK alpha   Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13 作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi 收藏  |  浏览/下载：82/0  |  提交时间：2020/12/24 grincamycin B  marine natural product  isocitrate dehydrogenase 1  apoptosis  ER stress  intracellular ROS  Zebrafish embryos  hematological malignancies   Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10 作者:  Yu, Yan-yan;  Cui, Shi-chao;  Zheng, Tian-nan;  Ma, Hai-jian;  Xie, Zhi-fu 收藏  |  浏览/下载：21/0  |  提交时间：2020/12/24 insulin resistance  sarsasapogenin  adipose tissue inflammation  macrophage-adipocyte crosstalk  IKK/NF-kappa B  JNK   Engineering the Phases and Heterostructures of Ultrathin Hybrid Perovskite Nanosheets 期刊论文 ADVANCED MATERIALS, 2020, 页码: 9 作者:  Sun, Yan;  Yin, Yao;  Pols, Mike;  Zhong, Jingxian;  Huang, Zhen 收藏  |  浏览/下载：51/0  |  提交时间：2020/12/24 2D materials  cation exchange  heterostructures  hybrid perovskites  phase engineering   Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9 作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei;  Xu, Ye-chun 收藏  |  浏览/下载：68/0  |  提交时间：2020/12/24 PDE5 inhibitor  TPN729  M3  species difference  pharmacokinetics  metabolite identification   Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor 期刊论文 ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2020, 卷号: 24, 期号: 6, 页码: 1175-1179 作者:  Zhang, Junchi;  Zhu, Fuqiang;  Tian, Guanghui;  Jiang, Xiangrui;  Shen, Jingshan 收藏  |  浏览/下载：21/0  |  提交时间：2020/12/24 6-chloro-5-methylpyridin-2-amine  lumacaftor  methylation  safe   Alopecines A-E, five chloro-containing matrine-type alkaloids with immunosuppressive activities from the seeds of Sophora alopecuroides 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 99, 页码: 5 作者:  Wang, Xiao-Feng;  Zhu, Zhengdan;  Hao, Ting-Ting;  Fang, Qiang-Qiang;  Jiang, Kun 收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 Sophora alopecuroides  Alkaloids  Cl-containing matrines  Absolute configuration  Immunosuppressive activity