Circuit oscillations  Dynamical systems  Inertial confinement fusion  Light sensitive materials  Neural networks  Neurons  Photocurrents  Photosensitivity  Stochastic systems  Chaotic oscillators  Complete synchronization  Non-linear oscillators  Non-uniform illumination  Stochastic disturbances  Synapse connections  Synchronization stability  Uniform illumination  

AUC-ROC,  area  under  receiver  operating  characteristic  BHB,  β-hydroxybutyric  acid  Biomarkers  C,  control  group  CA,  cholic  acid  CPT-11,  irinotecan  Complicating  toxicity  DBIL,  direct  bilirubin  DCA,  deoxycholic  acid  Diarrhea  FDR,  false  discovery  rate  GCA,  glycocholic  acid  Gastrointestinal  toxicity  IBIL,  indirect  bilirubin  IT-TOF/MS,  ion  trap/time-offlight  hybrid  mass  spectrometry  Individual  differences  Irinotecan  Lys,  lysine  MSTFA,  N-methyl-N-trifluoroacetamide  Metabolomics  NS,  non-sensitive  group  NSgt,  non-sensitive  for  gastrointestinal  toxicity  NSmt,  non-sensitive  for  myelosuppression  toxicity  OPLS-DA,  orthogonal  partial  least-squares-discriminant  analysis  PCA,  principal  component  analysis  PLS-DA,  partial  least-squares-discriminant  analysis  Phe,  phenylalanine  Prediction  QC,  quality  control  RSD,  relative  standard  deviation  S,  sensitive  group  Sgt,  sensitive  for  gastrointestinal  toxicity  Smt,  sensitive  for  myelosuppression  toxicity  T,  CPT-11  treated  group  Trp,  tryptophan  UFLC,  ultrafast  liquid  chromatography  VIP,  variable  importance  in  the  projection  pFDR,  false-discovery-rate-adjusted  P  value  

Body fluids  Color  Color vision  Drops  Glucose  Mechanical stability  Urea  Acquired immune deficiency syndrome  Industrial-scale applications  Non-invasive detection  Non-invasive diagnosis  Ph-responsive surfaces  Point-of-care testing  Sensitive detection  Theoretical calculations  Diseases  

CdTe quantum dots  Layer-by-layer self-assembly method  Measurement technologies  Non contact temperatures  Realization Technologies  Rolling bearings  Surface temperature information  Temperature sensitive  

Ultrasensitive detection of protein biomarkers is essential for early diagnosis and therapy of many diseases. Glycoproteins  differing from other types of proteins  contain carbohydrate moieties in the oligosaccharide chains. Boronic acid can form boronate ester covalent bonds with diol-containing species. Herein  we present a sensitive and cost-effective electrochemical method for glycoprotein detection using 4-mercaptophenylboronic acid (MBA)/biotin-modified gold nanoparticles (AuNPs) (MBA-biotin-AuNPs) as labels. To demonstrate the feasibility and sensitivity of this method  recombinant human erythropoietin (rHuEPO) was tested as a model analyte. Specifically  rHuEPO was captured by the anti-rHuEPO aptamer-covered electrode and then derivatized with MBA-biotin-AuNPs through the boronic acid–carbohydrate interaction. The MBA-biotin-AuNPs facilitated the attachment of streptavidin-conjugated alkaline phosphatase for the production of electroactive p-aminophenol from p-aminophenyl phosphate substrate. A detection limit of 8 fmol L-1 for rHuEPO detection was achieved. Other glycosylated and non-glycosylated proteins  such as horseradish peroxidase  prostate specific antigen  metallothionein  streptavidin  and thrombin showed no interference in the detection assay.