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	Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice
	Zhu, Li-Hua; Wang, Aibing; Luo, Pengcheng; Wang, Xinan; Jiang, Ding-Sheng; Deng, Wei; Zhang, Xiaofei; Wang, Tao; Liu, Yi; Gao, Lu
刊名	Journal of Hepatology
	2014
卷号	60期号:5页码:1046-1054
关键词	IR insulin resistance WT wild type KO knockout TG transgenic NTG non-transgenic NC normal chow HFD high-fat diet PPARα peroxisome proliferator-activated receptor alpha ECM extracellular matrix NL normal liver NAFLD non-alcoholic fatty liver disease H&E hematoxylin and eosin ALT alanine transaminase AST aspartate transaminase ALP alkaline phosphatase HMGCR 3-hydroxy-3-methyl-glutaryl-CoA reductase LDL low density lipoprotein HDL high density lipoprotein LDLR low-density lipoprotein receptor GPAT glycerol-3-phosphate acyltransferase DGAT diglyceride acyltransferase FFA free fatty acid SREBP1c sterol response element binding protein 1c ACC acetyl-CoA carboxylase FAS fatty acid synthase SCD stearoyl-CoA desaturase LXR-α liver X receptor-α ARG-1 arginase-1 ABCA ATP-binding cassette transporter A ABCG ATP-binding cassette transporter G CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 AMPK AMP-activated protein kinase IL interleukin TNF-α tumor necrosis factor alpha MCP-1 monocyte chemoattractant protein 1 MRC1 mannose receptor, C type 1 MGL macrophage galactose-type C-type lectin JNK Jun N-terminal kinase FBG fasting glucose HOMA-IR homeostasis model assessment of insulin resistance GTT glucose tolerance test ITT intraperitoneal insulin tolerance test Fins fasting insulin shRNA short hairpin RNA GFP green fluorescent protein IRS insulin receptor substrate Akt protein kinase B HSL hormone sensitive lipase ATGL adipose triacylglycerol lipase ACOX acyl-coenzyme A oxidase CPT-1α carnitine palmitoyltransferase-1-α LCAD long-chain acyl-CoA dehydrogenase MCAD medium-chain acyl-CoA dehydrogenase UCP uncoupling protein FGF21 fibroblast growth factor PPRE peroxisome proliferators response element AUC area under the curve IKKβ inhibitor of nuclear factor kappa B kinase beta subunit Spondin 2 Fatty liver Insulin resistance PPARα
ISSN号	0168-8278
DOI	10.1016/j.jhep.2014.01.011
URL标识	查看原文
WOS记录号	WOS:000334515000022
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/5115799
专题	湖南农业大学
作者单位	1.[Wang, Tao 2.Zhu, Li-Hua 3.Wang, Xinan 4.Li, Hongliang 5.Zhang, Shumin 6.Deng, Wei 7.Jiang, Ding-Sheng] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China.
推荐引用方式 GB/T 7714	Zhu, Li-Hua,Wang, Aibing,Luo, Pengcheng,et al. Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice[J]. Journal of Hepatology,2014,60(5):1046-1054.
APA	Zhu, Li-Hua.,Wang, Aibing.,Luo, Pengcheng.,Wang, Xinan.,Jiang, Ding-Sheng.,...&Li, Hongliang*.(2014).Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice.Journal of Hepatology,60(5),1046-1054.
MLA	Zhu, Li-Hua,et al."Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice".Journal of Hepatology 60.5(2014):1046-1054.

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