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科研机构
上海药物研究所 [24]
中国医学科学院 北京... [1]
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期刊论文 [25]
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2021 [1]
2020 [4]
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Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 5, 页码: 836-845
作者:
Che, Jinxin
;
Wang, Zhilong
;
Shen, Zheyuan
;
Zhuang, Weihao
;
Ying, Huazhou
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2021/08/17
cancer metastasis
CXCR1
CXCR2
selectivity
antagonist
1,5-dihydro-4H-imidazol-4-one
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
A fluorogenic probe for tracking GSH flux in developing neurons
期刊论文
CHEMICAL COMMUNICATIONS, 2020, 卷号: 56, 期号: 4, 页码: 515-518
作者:
Zong, Haichao
;
Peng, Jiayi
;
Li, Xiao-Rong
;
Liu, Meng
;
Hu, Yongzhou
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  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
Microenvironment-Responsive Small-Molecule Probe for Pulmonary Fibrosis Detection
期刊论文
ANALYTICAL CHEMISTRY, 2020, 卷号: 92, 期号: 1, 页码: 699-706
作者:
Dong, Ying
;
Li, Xiao-Rong
;
Chen, Qi
;
Guo, Rui-Ying
;
Tang, Bi-Xi
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  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:
Dong, Xiaowu
;
Zhan, Wenhu
;
Zhao, Mengting
;
Che, Jinxin
;
Dai, Xiaoyang
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  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:
Tong, Lexian
;
Song, Pinrao
;
Jiang, Kailong
;
Xu, Lei
;
Jin, Tingting
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
CHK1 kinase inhibitor
Selectivity
Monotherapy
Hematologic malignancies
Development of Macrocyclic Peptides Containing Epoxyketone with Oral Availability as Proteasome Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 20, 页码: 9177-9204
作者:
Li, Daqiang
;
Zhang, Xiaotuan
;
Ma, Xiaodong
;
Xu, Lei
;
Yu, Jianjun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents
期刊论文
ROYAL SOCIETY OPEN SCIENCE, 2018, 卷号: 5, 期号: 7
作者:
Che, Jinxin
;
Wang, Zhilong
;
Sheng, Haichao
;
Huang, Feng
;
Dong, Xiaowu
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
pharmacophore model
CXCR2
antagonists
anti-cancer metastasis
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