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上海药物研究所 [6]
复旦大学上海医学院 [2]
中国医学科学院 北京... [2]
北京大学 [1]
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期刊论文 [11]
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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y(12) inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing
期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 卷号: 127, 页码: 151-160
作者:
Li, Cai
;
Zhang, Yifan
;
Chen, Weili
;
Lu, Youming
;
Li, Wei
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2019/01/08
Vicagrel
Clopidogrel
P2Y(12) inhibitor
Pharmacokinetics
Active metabolite
Thienopyridine
Interval From Initiation of Prasugrel to Coronary Angiography in Patients With Non-ST-Segment Elevation Myocardial Infarction
期刊论文
2019, 卷号: 73, 期号: 8, 页码: 906-914
作者:
Silvain, Johanne
;
Rakowski, Tomasz
;
Lattuca, Benoit
;
Liu, Zhenyu
;
Bolognese, Leonardo
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/03
acute coronary syndrome
myocardial infarction
percutaneous coronary intervention
prasugrel
pretreatment
Evaluation of Tolerability, Pharmacokinetics and Pharmacodynamics of Vicagrel, a Novel P2Y12 Antagonist, in Healthy Chinese Volunteers
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Li, Xiaojiao
;
Liu, Ca
;
Zhu, Xiaoxue
;
Wei, Haijing
;
Zhang, Hong
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/01/08
vicagrel
pharmacokinetics
pharmacodynamics
safety
clopidogrel
Arylacetamide Deacetylase Is Involved in Vicagrel Bioactivation in Humans
期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:
Jiang, Jinfang
;
Chen, Xiaoyan
;
Zhong, Dafang
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  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
arylacetamide deacetylase
vicagrel
clopidogrel
hydrolytic metabolism
Human Liver Cytochrome P450 Enzymes and Microsomal Thiol Methyltransferase Are Involved in the Stereoselective Formation and Methylation of the Pharmacologically Active Metabolite of Clopidogrel
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 10, 页码: 1632-1641
作者:
Liu, Cai
;
Chen, Zhaoqiang
;
Zhong, Kan
;
Li, Liang
;
Zhu, Weiliang
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  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Structure of the human P2Y(12) receptor in complex with an antithrombotic drug
期刊论文
NATURE, 2014, 卷号: 509, 期号: 7498, 页码: 115-118
作者:
Zhang, Kaihua
;
Zhang, Jin
;
Gao, Zhan-Guo
;
Zhang, Dandan
;
Zhu, Lan
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  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
In Vitro Biotransformation Studies of 2-Oxo-clopidogrel: Multiple Thiolactone Ring-Opening Pathways Further Attenuate Prodrug Activation
期刊论文
毒物学领域的化学研究, 2013
Zhu, Yaoqiu
;
Zhou, Jiang
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  |  
浏览/下载:2/0
  |  
提交时间:2015/11/13
CLOPIDOGREL BIOACTIVATION
ACTIVE METABOLITE
IDENTIFICATION
TICLOPIDINE
RESISTANCE
PRASUGREL
THIENOPYRIDINE
DISPOSITION
INVOLVEMENT
GLUTATHIONE
Smoking and prasugrel
期刊论文
2013, 卷号: 168, 期号: 2, 页码: 1590-1591
作者:
Ye, Yicong
;
Xie, Hongzhi
;
Zhao, Xiliang
;
Zhang, Shuyang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
Prasugrel
Smoking
Clopidogrel
Esophageal mucosal lesion with low-dose aspirin and prasugrel mimics malignancy: A case report
期刊论文
WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 卷号: 17, 期号: 35
作者:
Ma, Gui-Fen
;
Gao, Hong
;
Chen, Shi-Yao
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/19
Esophageal injury
Low-dose aspirin
Prasugrel
Gastrointestinal hemorrhage
Drug-eluting stent
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