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Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
The inhibitory effect of 225 frequently-used traditional Chinese medicines for CYP3A4 metabolic enzyme by isoform-specific probe
期刊论文
FITOTERAPIA, 2021, 卷号: 152, 页码: 5
作者:
Wei, Wenlong
;
Li, Zhenwei
;
Li, Hao-jv
;
An, Yaling
;
Qu, Hua
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2021/08/17
Inhibitory effect
Frequently-used traditional Chinese medicines
Isoform-specific probe
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
期刊论文
DRUG METABOLISM AND DISPOSITION, 2021, 卷号: 49, 期号: 4, 页码: 305-313
作者:
Qiao, Shida
;
Feng, Sisi
;
Wu, Zhitao
;
He, Ting
;
Ma, Chen
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  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 8
作者:
Zhu, Yun-ting
;
Zhang, Yi-fan
;
Jiang, Jin-fang
;
Yang, Yong
;
Guo, Li-xia
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/05/24
Alflutinib
Rifampicin
CYP3A4
AST5902
Drug-drug interaction
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
收藏
  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma
期刊论文
BIOMEDICINE & PHARMACOTHERAPY, 2020, 卷号: 124, 页码: 14
作者:
Yuan, Lingyan
;
Bing, Zhitong
;
Han, Jiani
;
An, Xiaoli
;
Liu, Xingkui
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2022/01/18
Hepatocellular carcinoma
Bombyx batryticatus
Tumor microenvironment
Prognosis
Network pharmacology
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