Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma

doi:10.1016/j.biopha.2020.109838

	Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma
	Yuan, Lingyan 1,2,3,4,5; Bing, Zhitong 3,4,6,7; Han, Jiani 8; An, Xiaoli 9; Liu, Xingkui 10; Li, Rui 3,4,11; Wang, Caiyun 1,2,3,4; Sun, Xueqiang 1,2,3,4; Yang, Lei 6,7; Yang, Kehu 1,2,3,4
刊名	BIOMEDICINE & PHARMACOTHERAPY
	2020-04-01
卷号	124 页码:14
关键词	Hepatocellular carcinoma Bombyx batryticatus Tumor microenvironment Prognosis Network pharmacology
ISSN号	0753-3322
DOI	10.1016/j.biopha.2020.109838
通讯作者	Yang, Lei(lyang@impcas.ac.cn) ; Yang, Kehu(kehuyangebm2006@126.com)
英文摘要	Hepatocellular carcinoma (HCC) is a malignant primary liver cancer with poor prognosis. Most previous studies on anti-HCC effects of traditional Chinese medicines (TCM) have focused on the mechanism of direct action and few researchers considered that TCM can inhibit tumor progression and improve prognosis of HCC patients through regulating tumor microenvironment (TME). In this study, network pharmacology combined bioinformatics methods were employed to analysis mechanism of Bombyx batryticatus (B. batryticatus, one of the most frequently used traditional Chinese animal medicines, has been used in some Asian countries for centuries as an anticancer agent, anti-inflammatory agent, and antioxidant.) in regulating TME of HCC. The results showed that 24 core targets and 2 compounds were identified from overlapping between differential expression genes related to HCC in the cancer genome atlas (TCGA) database and targets of B. batryticatus in TCMSP database. For further analyzing the role of TME heterogeneity of HCC on anti-HCC mechanism of B. batryticatus, the correlation of core targets related with overall survival of HCC with TME cells in hepatitis C or hepatitis B virus-associated hepatocellular carcinoma (VIR) and non-hepatitis C or hepatitis B virus-associated hepatocellular carcinoma (NVIR) were calculated, respectively. The results showed that AKR1C3, SPP1 were significantly related with macrophages in VIR and other targets including NR1I2, CYP1A2 and CYP3A4 were significantly associated with macrophages in NVIR; the target protein AKR1C3 was significantly negative correlated with macrophages Ml in VIR (cor = -0.35, P-value < 0.001) and the correlation between AKR1C3 and macrophages Ml was poor in NVIR group (cor = 0.064, P-value = 0.36). Additionally, survival curve of AKR1C3 showed that poor prognosis in VIR group can be related to high level of AKR1C3 (HR = 2.32, 95 % CI: 1.18-4.56, P-value = 0.012), and no signified gene can be found in NVIR group (P-value > 0.05). In conclusion, the molecular mechanism of anti-HCC of B. batryticatus can be related to the tumor microenvironment to some extent. B. batryticatus may exert its anti-cancer effects and improve prognosis of patients by regulating macrophages Ml in VIR and NVIR through acting on different targets.
WOS关键词	MACROPHAGES ; EXPRESSION ; SURVIVAL ; QUALITY
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
WOS记录号	WOS:000512532600041
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/141043]
专题	中国科学院近代物理研究所
通讯作者	Yang, Lei; Yang, Kehu
作者单位	1.Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China 2.Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China 3.Lanzhou Univ, Sch Basic Med Sci, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China 4.Key Lab Evidence Based Med & Knowledge Translat G, Lanzhou, Peoples R China 5.Zunyi Med Univ, Sch Nursing, Zunyi, Guizhou, Peoples R China 6.Chinese Acad Sci, Inst Modern Phys, Dept Computat Phys, Lanzhou, Peoples R China 7.Univ Chinese Acad Sci, Sch Nucl Sci & Technol, Beijing, Peoples R China 8.Gansu Univ Chinese Med, Lanzhou, Peoples R China 9.Lanzhou Univ, State Key Lab Appl Organ Chem, Dept Chem, Lanzhou, Peoples R China 10.Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Clin Chinese Pharm, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Lingyan,Bing, Zhitong,Han, Jiani,et al. Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,124:14.
APA	Yuan, Lingyan.,Bing, Zhitong.,Han, Jiani.,An, Xiaoli.,Liu, Xingkui.,...&Yang, Kehu.(2020).Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma.BIOMEDICINE & PHARMACOTHERAPY,124,14.
MLA	Yuan, Lingyan,et al."Study on the anti-tumor mechanism related to immune microenvironment of Bombyx Batryticatus on viral and non-viral infections of hepatocellular carcinoma".BIOMEDICINE & PHARMACOTHERAPY 124(2020):14.