Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China

doi:10.2174/1389200221666200929115117

	Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
	Yu, Xuan 1,2; Chu, Zixuan 1,2; Li, Jian 2; He, Rongrong 2,3; Wang, Yaya 2,3; Cheng, Chen 2
刊名	CURRENT DRUG METABOLISM
	2021
卷号	22 期号:1 页码:5-23
关键词	Pharmacokinetics drug-drug interaction antibiotic sepsis transporter enzyme
ISSN号	1389-2002
DOI	10.2174/1389200221666200929115117
通讯作者	Cheng, Chen(chengchen@simm.ac.cn)
英文摘要	Background: Many antibiotics have a high potential for interactions with drugs, as a perpetrator and/or victim, in critically ill patients, and particularly in sepsis patients. Methods: The aim of this review is to summarize the pharmacokinetic drug-drug interaction (DDI) of 45 antibiotics commonly used in sepsis care in China. Literature search was conducted to obtain human pharmacokinetics/dispositions of the antibiotics, their interactions with drug-metabolizing enzymes or transporters, and their associated clinical drug interactions. Potential DDI is indicated by a DDI index >= 0.1 for inhibition or a treatedcell/untreated-cell ratio of enzyme activity being >= 2 for induction. Results: The literature-mined information on human pharmacokinetics of the identified antibiotics and their potential drug interactions is summarized. Conclusion: Antibiotic-perpetrated drug interactions, involving P450 enzyme inhibition, have been reported for four lipophilic antibacterials (ciprofloxacin, erythromycin, trimethoprim, and trimethoprim-sulfamethoxazole) and three antifungals (fluconazole, itraconazole, and voriconazole). In addition, seven hydrophilic antibacterials (ceftriaxone, cefamandole, piperacillin, penicillin G, amikacin, metronidazole, and linezolid) inhibit drug transporters in vitro. Despite no clinical PK drug interactions with the transporters, caution is advised in the use of these antibacterials. Eight hydrophilic antibiotics (all beta-lactams; meropenem, cefotaxime, cefazolin, piperacillin, ticarcillin, penicillin G, ampicillin, and flucloxacillin), are potential victims of drug interactions due to transporter inhibition. Rifampin is reported to perpetrate drug interactions by inducing CYP3A or inhibiting OATP1B; it is also reported to be a victim of drug interactions, due to the dual inhibition of CYP3A4 and OAT-P1B by indinavir. In addition, three antifungals (caspofungin, itraconazole, and voriconazole) are reported to be victims of drug interactions because of P450 enzyme induction. Reports for other antibiotics acting as victims in drug interactions are scarce.
WOS关键词	CRITICALLY-ILL PATIENTS ; INTERNATIONAL CONSENSUS DEFINITIONS ; MULTIPLE-DOSE PHARMACOKINETICS ; BETA-LACTAM ANTIBIOTICS ; INTRAVENOUSLY ADMINISTERED CEFOPERAZONE ; ANION-TRANSPORTING POLYPEPTIDES ; 22 ANTITUBERCULOSIS DRUGS ; AMPHOTERICIN-B AMBISOME ; IN-VITRO INHIBITION ; SALT EXPORT PUMP
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种	英语
出版者	BENTHAM SCIENCE PUBL LTD
WOS记录号	WOS:000625302200003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295483]
专题	中国科学院上海药物研究所
通讯作者	Cheng, Chen
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin 300193, Peoples R China
推荐引用方式 GB/T 7714	Yu, Xuan,Chu, Zixuan,Li, Jian,et al. Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China[J]. CURRENT DRUG METABOLISM,2021,22(1):5-23.
APA	Yu, Xuan,Chu, Zixuan,Li, Jian,He, Rongrong,Wang, Yaya,&Cheng, Chen.(2021).Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China.CURRENT DRUG METABOLISM,22(1),5-23.
MLA	Yu, Xuan,et al."Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China".CURRENT DRUG METABOLISM 22.1(2021):5-23.