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科研机构
上海药物研究所 [108]
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期刊论文 [108]
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2021 [8]
2020 [6]
2019 [9]
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A general strategy to the intracellular sensing of glycosidases using AIE-based glycoclusters
期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 13, 期号: 1, 页码: 247-256
作者:
Dong, Lei
;
Zhang, Min-Yu
;
Han, Hai-Hao
;
Zang, Yi
;
Chen, Guo-Rong
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/01/18
Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Wang, Lin
;
Wu, Yan
;
Yao, Sheng
;
Ge, Huan
;
Zhu, Ya
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  |  
浏览/下载:86/0
  |  
提交时间:2021/11/04
SARS-CoV-2
natural products
virtual screening
spike protein
protein-protein interaction modulators
Stimuli-Sheddable Nanomedicine Overcoming Pathophysiological Barriers for Potentiating Immunotherapy of Cancer
期刊论文
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2021, 卷号: 17, 期号: 8, 页码: 1486-1509
作者:
Wang, Jiaxin
;
Zhou, Mengxue
;
Chen, Fangmin
;
Liu, Xiao
;
Gao, Jin
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  |  
浏览/下载:40/0
  |  
提交时间:2021/11/04
Cancer Immunotherapy
Tumor Microenvironment
Stimuli-Responsiveness
Sheddable Nanoparticles
Pathophysiological Barriers
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 7, 页码: 1885-1902
作者:
Wu, Xu
;
Yin, Chun
;
Ma, Jiang
;
Chai, Stella
;
Zhang, Chunyuan
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/11/04
Multidrug resistance
ABCB1
Polyoxypregnane
Combination chemotherapy
Marsdenia tenacissima
Discovery of novel reversible monoacylglycerol lipase inhibitors via docking-based virtual screening
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 6
作者:
Xiong, Fengmin
;
Ding, Xiaoyu
;
Zhang, Hao
;
Luo, Xiaomin
;
Chen, Kaixian
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/08/17
Monoacylglycerol lipase
Inhibitor
Virtual screening
Inflammation
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
TSL-1502, a glucuronide prodrug of a poly (ADP-ribose) polymerase (PARP) inhibitor, exhibits potent anti-tumor activity in preclinical models
期刊论文
AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 卷号: 11, 期号: 4, 页码: 1632-1645
作者:
Wang, Lei
;
Zhu, Xi
;
Li, Lili
;
Li, Lin
;
Fu, Li
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  |  
浏览/下载:75/0
  |  
提交时间:2021/06/11
PARP
DNA damage
hematologic toxicity
beta-glucuronidase
tumor selectivity
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 203, 页码: 19
作者:
Che, Jinxin
;
Huang, Feng
;
Zhang, Mengmeng
;
Xu, Gaoya
;
Qu, Bingxue
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/12/21
Metabolic pathways
Isocitrate dehydrogenase 2
Conformational restriction
Macrocyclic derivatives
Inhibitors
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