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浏览/检索结果: 共25条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun 收藏  |  浏览/下载：75/0  |  提交时间：2020/07/01 PI3K alpha inhibitors  proliferation inhibition  thieno[3  2-d]pyrimidine derivatives   A complex structure of arrestin-2 bound to a G protein-coupled receptor 期刊论文 CELL RESEARCH, 2019, 卷号: 29, 期号: 12, 页码: 971-983 作者:  Yin, Wanchao;  Li, Zhihai;  Jin, Mingliang;  Yin, Yu-Ling;  de Waal, Parker W. 收藏  |  浏览/下载：85/0  |  提交时间：2020/07/01 Colocalization Strategy Unveils an Underside Binding Site in the Transmembrane Domain of Smoothened Receptor 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 21, 页码: 9983-9989 作者:  Zhou, Fang;  Ding, Kang;  Zhou, Yiqing;  Liu, Yang;  Liu, Xiaoyan 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 Targeting the N Terminus of eIF4AI for Inhibition of Its Catalytic Recycling 期刊论文 CELL CHEMICAL BIOLOGY, 2019, 卷号: 26, 期号: 10, 页码: 1417-+ 作者:  Jiang, Chenxiao;  Tang, Yegen;  Ding, Lulu;  Tan, Renke;  Li, Xiaojing 收藏  |  浏览/下载：14/0  |  提交时间：2020/07/01 fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85 作者:  Zhan, Wenhu;  Che, Jinxin;  Xu, Lei;  Wu, Yizhe;  Hu, Xiaobei 收藏  |  浏览/下载：15/0  |  提交时间：2020/07/01 Pyrazole-thiophene derivatives  Akt inhibitor  Antitumor   Molecular Mechanism of Binding Selectivity of Inhibitors toward BACE1 and BACE2 Revealed by Multiple Short Molecular Dynamics Simulations and Free-Energy Predictions 期刊论文 ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 10, 页码: 4303-4318 作者:  Chen, Jianzhong;  Wang, Jinan;  Yin, Baohua;  Pang, Laixue;  Wang, Wei 收藏  |  浏览/下载：114/0  |  提交时间：2020/07/01 beta-amyloid cleaving enzyme  binding selectivity  MSMD  hierarchical clustering analysis  MM-GBSA   Structural and functional studies of USP20 ZnF-UBP domain by NMR 期刊论文 PROTEIN SCIENCE, 2019, 卷号: 28, 期号: 9, 页码: 1606-1619 作者:  Yang, Yuanyuan;  Ding, Yiluan;  Zhou, Chen;  Wen, Yi;  Zhang, Naixia 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 deubiquitinase  NMR  solution structure  USP20  ZnF-UBP domain   New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp. 期刊论文 STEROIDS, 2019, 卷号: 149, 页码: 5 作者:  Jiang, Cheng-Shi;  Ru, Tong;  Huan, Xia-Juan;  Miao, Ze-Hong;  Guo, Yue-Wei 收藏  |  浏览/下载：43/0  |  提交时间：2020/07/01 Soft coral  Sinularia sp.  Ergostane  Antiproliferative activity  Apoptosis   Discovery and Biological evaluation of pyrimido[4,5-d] pyrimidine-2,4(1H, 3H)-dione derivatives as potent Bruton's tyrosine kinase inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 15, 页码: 3390-3395 作者:  Diao, Yanyan;  Fang, Xiaoyu;  Song, Peiran;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 Bruton's tyrosine kinase  B-cell malignancies  Potent inhibitors  Structure-activity relationship  Cellular activities   Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities 期刊论文 MOLECULES, 2019, 卷号: 24, 期号: 13, 页码: 18 作者:  Zhu, Haodong;  Liu, Chen;  Hou, Jinjun;  Long, Huali;  Wang, Bing 收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 Gastrodia elata Bl (G  elata)  polysaccharides  phytochemistry  pharmacological action