New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.

doi:10.1016/j.steroids.2019.108425

	New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.
	Jiang, Cheng-Shi 1; Ru, Tong 2,3; Huan, Xia-Juan 2,3; Miao, Ze-Hong 2,3; Guo, Yue-Wei 2,3,4
刊名	STEROIDS
	2019-09-01
卷号	149 页码:5
关键词	Soft coral Sinularia sp. Ergostane Antiproliferative activity Apoptosis
ISSN号	0039-128X
DOI	10.1016/j.steroids.2019.108425
通讯作者	Jiang, Cheng-Shi(bio_jiangcs@ujn.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Two new highly oxygenated ergostane-type sterols (1, 2) together with one known related compound sinugrandisterol A (3) were isolated from the soft coral Sinularia sp. collected from the water area near the Xisha Islands, South China Sea. Their structures were elucidated on the basis of detailed spectroscopic analysis, chemical transformations, and by comparison with those reported in literature. In bioassays, compounds 1 and 2 showed in vitro antiproliferative activity against a panel of cancer cell lines, including MDA-MB-436, A549, Hep3B, HT-29 and H157. Morphological observation and Hoechst 33,258 staining assays showed that compound 1-treated H157 cells displayed apoptosis characteristics. Moreover, western blot assays suggested that 1 could increase the expression of Bax and down-regulate expression of Bcl-2.
资助项目	Drug Innovation Major Project[2018ZX09711-001-001-009] ; State Key Basic Research Program of the PRC[2018YFC0310903] ; NSFC-Shandong Joint Fund for Marine Science Research Center[U1606403] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; SKLDR/SIMM Project[SIMM1903ZZ-04]
WOS关键词	POLYHYDROXYLATED STEROIDS ; TIRUCALLANE TRITERPENES ; ROOTS
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000477788300013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289205]
专题	中国科学院上海药物研究所
通讯作者	Jiang, Cheng-Shi; Guo, Yue-Wei
作者单位	1.Univ Jinan, Sch Biol Sci & Technol, 336 West Rd Nan Xinzhuang, Jinan 250022, Shandong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangiiang Hitech Pk, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Lead Cpds, Wenhai Rd, Qingdao 266237, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Cheng-Shi,Ru, Tong,Huan, Xia-Juan,et al. New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.[J]. STEROIDS,2019,149:5.
APA	Jiang, Cheng-Shi,Ru, Tong,Huan, Xia-Juan,Miao, Ze-Hong,&Guo, Yue-Wei.(2019).New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp..STEROIDS,149,5.
MLA	Jiang, Cheng-Shi,et al."New New cytotoxic ergostane-type sterols from the Chinese soft coral Sinularia sp.".STEROIDS 149(2019):5.