CORC

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CORC

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Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma 期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:  Chen, Zi-qi;  Cao, Zhe-rui;  Wang, Yi;  Zhang, Xi;  Xu, Lan
收藏  |  浏览/下载：50/0  |  提交时间：2021/12/16
CYH33  MYC  P300  BET  B cell lymphoma  PI3K  
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:  Zhang, Xi;  Duan, Yu-ting;  Wang, Yi;  Zhao, Xing-dong;  Sun, Yi-ming
收藏  |  浏览/下载：34/0  |  提交时间：2021/05/24
Adaptive resistance to PI3K alpha-selective inhibitor CYH33 is mediated by genomic and transcriptomic alterations in ESCC cells 期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 1, 页码: 13
作者:  Wang, Yu-xiang;  Zhang, Xu;  Ma, Qing-yang;  Hu, Lan-dian;  Zhang, Xi
收藏  |  浏览/下载：44/0  |  提交时间：2021/05/24
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:  Xiang, Hao-Yue;  Wang, Xiang;  Chen, Yan-Hong;  Zhang, Xi;  Tan, Cun
收藏  |  浏览/下载：33/0  |  提交时间：2021/05/24
Discovery of 2-(5-(quinolin-6-yl)-1,3,4-oxadiazol-2-yl)acetamide derivatives as novel PI3K alpha inhibitors via docking-based virtual screening 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 29, 页码: 9
作者:  Gu, Dongyan;  Cheng, Gang;  Zhang, Mengmeng;  Zhou, Yu-Bo;  Li, Jia
收藏  |  浏览/下载：15/0  |  提交时间：2021/05/24
PI3K alpha inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8(+)T cells and promoting fatty acid metabolism 期刊论文
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 卷号: 9, 期号: 8, 页码: 16
作者:  Sun, Pu;  Zhang, Xi;  Wang, Rong-Jing;  Ma, Qing-Yang;  Xu, Lan
收藏  |  浏览/下载：41/0  |  提交时间：2021/11/04
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4
作者:  Xiang, Hao-Yue;  Chen, Yan-Hong;  Wang, Yi;  Zhang, Xi;  Ding, Jian
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01
Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii LGT-4, Cultured in CYM Medium 期刊论文
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020, 卷号: 19, 期号: 2, 页码: 259-263
作者:  Yang, Zhong-Duo;  Zhang, Yu;  Zhao, Wei-Hua;  Shu, Zong-Mei
收藏  |  浏览/下载：7/0  |  提交时间：2022/03/01
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun
收藏  |  浏览/下载：75/0  |  提交时间：2020/07/01
Wortmannine F and G, two new pyranones from Talaromyces wortmannii LGT-4, the endophytic fungus of Tripterygium wilfordii 期刊论文
PHYTOCHEMISTRY LETTERS, 2019, 卷号: 29, 页码: 115-118
作者:  Zhao, Jun-Wen;  Yang, Zhong-Duo;  Zhou, Shuan-Yan;  Yang, Li-Jun;  Sun, Jian-Hui
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/15

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