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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 发表日期：2018    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3693-3699 作者:  Zhu, Kongkai;  Song, Jia-Li;  Tao, Hong-Rui 收藏  |  浏览/下载：100/0  |  提交时间：2019/01/08 Pharmacophore combination  Isoquinoline  PRMT5 inhibitor  Molecular docking  Molecular dynamics simulation   ETA as a novel Kv2.1 inhibitor ameliorates beta-cell dysfunction and hyperglycaemia 期刊论文 CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2018, 卷号: 45, 期号: 12, 页码: 1257-1264 作者:  Zhou, Tingting;  Du, Mengfan;  Zhao, Tong;  Quan, Lingling;  Zhu, Zhiyuan 收藏  |  浏览/下载：94/0  |  提交时间：2019/01/08 beta cell  apoptosis  glucose-stimulated insulin secretion  T2DM   Cyclopeptide RA-V Inhibits Organ Enlargement and Tumorigenesis Induced by YAP Activation 期刊论文 CANCERS, 2018, 卷号: 10, 期号: 11 作者:  Ji, Xinyan;  Song, Lihua;  Sheng, Li;  Gao, Anhui;  Zhao, Yang 收藏  |  浏览/下载：77/0  |  提交时间：2019/01/08 hippo pathway  YAP  TAZ  RA-V  cancer  organ size  protein synthesis   Difuran-substituted quinoxalines as a novel class of PI3K alpha H1047R mutant inhibitors: Synthesis, biological evaluation and structure activity relationship 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 157, 页码: 37-49 作者:  Zhang, Ning;  Yu, Zhimei;  Yang, Xiaohong;  Zhou, Yan;  Tang, Qing 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 Proliferation  Anticancer drug  Phosphatidylinositol 3-kinase inhibitor  Apoptosis  Structure-activity relationship   Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats 期刊论文 FRONTIERS IN PSYCHIATRY, 2018, 卷号: 9 作者:  Shen, Fu-Yi;  Song, Ying-Cai;  Guo, Fei;  Xu, Zhen-Dong;  Li, Qian 收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08 sevoflurane  repeated exposure  cognitive dysfunction  synaptic plasticity  endoplasmic reticulum stress   Dihydrocelastrol exerts potent antitumor activity in mantle cell lymphoma cells via dual inhibition of mTORC1 and mTORC2 期刊论文 INTERNATIONAL JOURNAL OF ONCOLOGY, 2018, 卷号: 53, 期号: 2, 页码: 823-834 作者:  Xie, Yongsheng;  Li, Bo;  Bu, Wenxuan;  Gao, Lu;  Zhang, Yong 收藏  |  浏览/下载：98/0  |  提交时间：2019/01/08 mantle cell lymphoma  dihydrocelastrol  apoptosis  cell cycle  mTORC1  mTORC2   DCZ3301, a novel aryl-guanidino inhibitor, induces cell apoptosis and cell cycle arrest via suppressing the PI3K/AKT pathway in T-cell leukemia/lymphoma 期刊论文 ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 卷号: 50, 期号: 7, 页码: 643-650 作者:  Xiao, Wenqin;  Li, Bo;  Sun, Xi;  Yu, Dandan;  Xie, Yongsheng 收藏  |  浏览/下载：82/0  |  提交时间：2019/01/08 DCZ3301  T-cell leukemia/lymphoma  apoptosis  cell cycle  PI3K/AKT   Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 151, 页码: 740-751 作者:  Xiong, Huan;  Han, Jie;  Wang, Jun;  Lu, Wenchao;  Wang, Chen 收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 Epigenetics  Histone acetyltransferase  GCN5  High throughput screening  1,8-Acridinedione derivative   Identification of Selective, Cell Active Inhibitors of Protein Arginine Methyltransferase 5 through Structure-Based Virtual Screening and Biological Assays 期刊论文 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 卷号: 58, 期号: 5, 页码: 1066-1073 作者:  Ye, Fei;  Zhang, Weiyao;  Ye, Xiaoqing;  Jin, Jia;  Lv, Zhengbing 收藏  |  浏览/下载：15/0  |  提交时间：2019/01/08 Protopanaxadiol derivative DDPU improves behavior and cognitive deficit in AD mice involving regulation of both ER stress and autophagy 期刊论文 NEUROPHARMACOLOGY, 2018, 卷号: 130, 页码: 77-91 作者:  Guo, Xiaodan;  Lv, Jianlu;  Lu, Jian;  Fan, Lei;  Huang, Xi 收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 Alzheimer's disease  Ginseng  Autophagy  BACE1  ER stress  Amyloid beta  Apoptosis  APP/PS1 transgenic mice