Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats

doi:10.3389/fpsyt.2018.00332

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第二研究室

	Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats
	Shen, Fu-Yi 3; Song, Ying-Cai 3; Guo, Fei 1; Xu, Zhen-Dong 3; Li, Qian 3; Zhang, Bing 1,2,3; Ma, Yu-Qin 1,2; Zhang, Yue-Qi 3; Lin, Rong 3; Li, Yang1
刊名	FRONTIERS IN PSYCHIATRY
	2018-08-02
卷号	9
关键词	sevoflurane repeated exposure cognitive dysfunction synaptic plasticity endoplasmic reticulum stress
ISSN号	1664-0640
DOI	10.3389/fpsyt.2018.00332
文献子类	Article
英文摘要	Sevoflurane is one of the most commonly used volatile anaesthetics for children, but the safety of prolonged or repeated clinical use of sevoflurane in infants or children is controversial. Here, we investigated the effects of sevoflurane on rats in early life and the time scale of those effects. Our behavioral results indicated that repeated short-term exposure of new-born rats to sevoflurane caused learning and memory impairment, while a single exposure of rats to sevoflurane was relatively safe. Further mechanistic investigation revealed that repeated sevoflurane exposure impaired long-term potentiation (LTP), downregulated the expression of certain synaptogenesis-related proteins (GluR1, PSD95) and upregulated proteins related to endoplasmic reticulum (ER) stress in the hippocampus. An ER stress inhibitor, tauroursodeoxycholic acid (TUDCA), reversed the changes in the levels of synaptic plasticity proteins. Our results provide new evidence for the clinical concerns regarding repeated sevoflurane anesthesia.
资助项目	China National Natural Science Foundation[31200771] ; China National Natural Science Foundation[31171011] ; China National Natural Science Foundation[31371066] ; China National Natural Science Foundation[31671049] ; China National Natural Science Foundation[81771188] ; Science and Technology Commission of Shanghai Municipality[14411966700] ; Science and Technology Commission of Shanghai Municipality[16411967400] ; Shanghai Municipal Health and Family Planning Commission[20144Y0209] ; Shanghai Municipal Health and Family Planning Commission[20134y129] ; Shanghai municipal medical and health discipline construction projects[2017ZZ02015] ; "Xinchen Cup" Young Anaesthesiologists Incubation Fund of Shanghai Medical Association Anaesthesiology Branch[00000000]
WOS关键词	UNFOLDED PROTEIN RESPONSE ; ELEMENT-BINDING PROTEIN ; SYNAPTIC PLASTICITY ; TRANSLATIONAL CONTROL ; NEURONAL APOPTOSIS ; CHILDHOOD EXPOSURE ; CELL-SURVIVAL ; BIRTH COHORT ; IN-VIVO ; ANESTHESIA
WOS研究方向	Psychiatry
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000440578800002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279628]
专题	药理学第二研究室
通讯作者	Li, Yang; Liu, Zhi-Qiang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Tongji Univ, Sch Med, Shanghai Matern & Infant Hosp 1, Dept Anesthesiol, Shanghai, Peoples R China;
推荐引用方式 GB/T 7714	Shen, Fu-Yi,Song, Ying-Cai,Guo, Fei,et al. Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats[J]. FRONTIERS IN PSYCHIATRY,2018,9.
APA	Shen, Fu-Yi.,Song, Ying-Cai.,Guo, Fei.,Xu, Zhen-Dong.,Li, Qian.,...&Liu, Zhi-Qiang.(2018).Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats.FRONTIERS IN PSYCHIATRY,9.
MLA	Shen, Fu-Yi,et al."Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats".FRONTIERS IN PSYCHIATRY 9(2018).