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上海药物研究所 [29]
上海大学 [1]
中国医学科学院 北京... [1]
合肥物质科学研究院 [1]
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期刊论文 [31]
会议论文 [1]
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2021 [3]
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Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 8
作者:
Song, Zilan
;
Liu, Yuting
;
Xie, Chenghu
;
Tong, Xiankun
;
Wang, Xue
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2021/11/04
Choroquine
Aminochloroquine
Antivirus
Anti-inflammatory
Cytokines
Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRAS(G12C) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 213, 页码: 17
作者:
Xiao, Xuanzheng
;
Lai, Mengzhen
;
Song, Zilan
;
Geng, Meiyu
;
Ding, Jian
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2021/05/24
KRAS
Covalent inhibitor
Pyridopyrimidinone
Antiproliferative effect
Scaffold hopping
Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 3, 页码: 1649-1669
作者:
Song, Zilan
;
Wang, Xiyuan
;
Zhang, Yan
;
Gu, Wangting
;
Shen, Ancheng
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/05/24
Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 12, 页码: 2272-2298
作者:
Ding, Chunyong
;
Song, Zilan
;
Shen, Ancheng
;
Chen, Tingting
;
Zhang, Ao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Immunotherapy
Anti-tumor
cGAS
STING
TBK1
Small molecule modulators
Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core (vol 26, pg 5399, 2016)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 1
作者:
Han, Mei
;
Wang, Chengyan
;
Ji, Yinchun
;
Song, Zilan
;
Xing, Li
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo [d] azepin-7-yl)amino)pyrazine core
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 836-838
作者:
Wang, Yueliang
;
Xing, Li
;
Ji, Yinchun
;
Ye, Jiqing
;
Dai, Yang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
AXL Kinase
Pyrazine
Cancer
Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo [d] azepin-7-yl)amino)pyrazine core
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 页码: 836-838
作者:
Wang, Yueliang[1]
;
Xing, Li[2]
;
Ji, Yinchun[3]
;
Ye, Jiqing[4]
;
Dai, Yang[5]
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/04/22
AXL Kinase
Pyrazine
Cancer
Small-Molecule Immuno-Oncology Therapy: Advances, Challenges and New Directions
期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2019, 卷号: 19, 期号: 3, 页码: 180-185
作者:
Chen, Shulun
;
Song, Zilan
;
Zhang, Ao
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-l-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 9-28
作者:
Wei, Manman
;
Peng, Xia
;
Xing, Li
;
Dai, Yang
;
Huang, Ruimin
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2019/01/08
FGFR
VEGFR
Synergistic effect
Tumor growth inhibition
Lucitanib
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86
作者:
Geng, Kaijun
;
Liu, Hongchun
;
Song, Zilan
;
Zhang, Chi
;
Zhang, Minmin
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  |  
浏览/下载:147/0
  |  
提交时间:2019/01/08
Heat shock protein 90 (Hsp90)
Tyrosine kinase ALK
Dual inhibitor
Drug resistance
Antiproliferative activity
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