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北京大学 [43]
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期刊论文 [226]
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Receptor-Ligand Binding: Effect of Mechanical Factors
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 10, 2023, 卷号: 24, 页码: 9062
作者:
Du, Ruotian
;
Li L(李龙)
;
Ji, Jing
;
Fan, Yubo
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/06/15
receptor-ligand binding
tension
shear stress
stretch
compression
substrate stiffness
biomechanics
mechanotransduction
Insights into intercellular receptor-ligand binding kinetics in cell communication
期刊论文
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2022, 卷号: 10, 页码: 953353
作者:
An, Chenyi
;
Wang, Xiaohuan
;
Song F(宋凡)
;
Hu, Jinglei
;
Li L(李龙)
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2022/10/23
cell communication
intercellular receptor-ligand binding kinetics
protein-membrane interaction
biomechanical force
bioelectric microenvironment
CSConv2d: A 2-D Structural Convolution Neural Network with a Channel and Spatial Attention Mechanism for Protein-Ligand Binding Affinity Prediction
期刊论文
BIOMOLECULES, 2021, 卷号: 11, 期号: 5, 页码: 9
作者:
Wang, Xun
;
Liu, Dayan
;
Zhu, Jinfu
;
Rodriguez-Paton, Alfonso
;
Song, Tao
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2021/12/01
protein-ligand binding affinity
2-D structural CNN
spatial attention mechanism
Interplay Between Receptor-Ligand Binding and Lipid Domain Formation Depends on the Mobility of Ligands in Cell-Substrate Adhesion
期刊论文
FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 卷号: 8, 页码: 9
作者:
Li L(李龙)
;
Wang XH(王小环)
;
Wu, Helong
;
Shao YF(邵颖峰)
;
Wu, Huaping
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  |  
浏览/下载:90/0
  |  
提交时间:2021/05/31
cell adhesion
receptor-ligand binding
nanoscale lipid cluster
ligand mobility
phase separation
binding constant
德克隆类化合物对甲状腺系统的干扰效应及其分子机制
学位论文
北京: 中国科学院生态环境研究中心, 2020
作者:
朱剑桥
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  |  
浏览/下载:16/0
  |  
提交时间:2021/07/07
德克隆类化合物、甲状腺激素受体、竞争结合、t-screen、报告基因
Dechloranes, Thyroid Hormone Receptor, Ligand Binding Assay, T-screen Assay, Reporter Gene Assay
The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses
期刊论文
FRONTIERS IN IMMUNOLOGY, 2020, 卷号: 11, 页码: 22
作者:
Lv, Zhao
;
Qiu, Limei
;
Wang, Weilin
;
Liu, Zhaoqun
;
Liu, Qing
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/09/25
Crassostrea gigas
integrin family
immune function
ECM ligand binding
functional division and cooperation
Simulative structure and binding sites of lyral with olfactory receptor 10J5 using computational prediction methods
期刊论文
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2020, 卷号: 83, 期号: 1, 页码: 1-8
作者:
Wang, P (Wang, Pu)[ 1 ]
;
Zhang, R (Zhang, Rui)[ 2,3 ]
;
Yu, SB (Yu, Shunbang)[ 1 ]
;
Lee, C (Lee, Charles)[ 4 ]
;
Wang, H (Wang, He)[ 1 ]
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/03/16
Homology modeling
ligand docking
binding sites
olfactory receptor
lyral
Structure-Based Survey of the Binding Modes of BACE1 Inhibitors
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 2, 页码: 880-889
作者:
Hu, Hangchen
;
Chen, Zhaoqiang
;
Xu, Xiang
;
Xuo, Yechun
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
BACE1
Alzheimer's disease
inhibitor
ligand binding mode
subsite
substructure
Direct SUMOylation of M1 muscarinic acetylcholine receptor increases its ligand-binding affinity and signal transduction
期刊论文
FASEB JOURNAL, 2019, 卷号: 33, 期号: 3
作者:
Xu, Jianrong
;
Tan, Panpan
;
Li, Hui
;
Cui, Yongyao
;
Qiu, Yu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/12/05
site-directed mutagenesis
GPCR
agonist
radio-ligand binding
Evaluation of selected traditional Chinese medical extracts for bone mineral density maintenance: A mechanistic study.
期刊论文
Journal of traditional and complementary medicine, 2019, 卷号: 9, 期号: 3
作者:
Rebhun John F
;
Du Qin
;
Hood Molly
;
Guo Hailing
;
Glynn Kelly M
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/12/05
Anti-inflammatory
BMD, bone mineral density
BSA, bovine serum albumin
Bmp4, bone morphogenic protein 4
CRE, cyclic adenosine monophosphate response element
CREB, cyclic adenosine monophosphate response element binding protein
DEXA, dual-energy X-ray absorptiometry
DMSO, Dimethyl sulfoxide
Drynaria fortunei
E2, estradiol
ER, estrogen receptor
ERE, estrogen response element
Epimedium brevicornu
Estrogenic
FBS, fetal bovine serum
Fsk, forskolin
Hprt, hypoxanthine-guanine phosphoribosyl-transferase
IL-1, interleukin 1
LBD, ligand binding domain
LBM, low bone mass
M-CSF, macrophage colony-stimulating factor
MAPK, mitogen activated protein kinase
NF-κβ, nuclear factor kappa beta
OP, osteoporosis
Osteoporosis
PTH, parathyroid hormone
PTHrp, PTH related peptide
RANKL, receptor activator of nuclear factor kappa beta ligand
RLU, relative luminescence unit
ROI, region of interest
Runx2, runt-related transcription factor 2
SFM, serum free media
TCM, traditional Chinese medicine
TNFα, tumor necrosis factor alpha
TRAP, tartrate-resistant acid phosphatase
UAS, upstream activating sequence
cAMP, cyclic adenosine monophosphate
qPCR, quantitative polymerase chain reaction
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