Receptor-Ligand Binding: Effect of Mechanical Factors

doi:10.3390/ijms24109062

CORC > 力学研究所 > 中国科学院力学研究所 > 非线性力学国家重点实验室

	Receptor-Ligand Binding: Effect of Mechanical Factors
	Du, Ruotian ; Li L(李龙); Ji, Jing ; Fan, Yubo
刊名	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES ; 10
	2023-05
卷号	24 页码:9062
关键词	receptor-ligand binding tension shear stress stretch compression substrate stiffness biomechanics mechanotransduction
ISSN号	1661-6596
DOI	10.3390/ijms24109062
英文摘要	Gaining insight into the in situ receptor-ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor-ligand binding responds to mechanical stimuli. This review aims to provide an overview of the current understanding of the effect of several representative mechanical factors, such as tension, shear stress, stretch, compression, and substrate stiffness on receptor-ligand binding, wherein the biomedical implications are focused. In addition, we highlight the importance of synergistic development of experimental and computational methods for fully understanding the in situ receptor-ligand binding, and further studies should focus on the coupling effects of these mechanical factors.
分类号	二类
WOS研究方向	WOS:000996574800001
语种	英语
资助机构	National Natural Science Foundation of China [12232019, 12272388, 11972041, 11902327, U20A20390, 11827803] ; Youth Innovation Promotion Association CAS
其他责任者	Ji, J ; Li, L
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/92272]
专题	力学研究所_非线性力学国家重点实验室
作者单位	1.(Li Long) Chinese Acad Sci Inst Mech State Key Lab Nonlinear Mech Beijing Key Lab Engn Construct & Mechanobiol Beijing 100190 Peoples R China 2.(Du Ruotian, Ji Jing, Fan Yubo) Beihang Univ Beijing Adv Innovat Ctr Biomed Engn Sch Biol Sci & Med Engn Key Lab Biomech & MechanobiolMinist Educ Beijing 100191 Peoples R China
推荐引用方式 GB/T 7714	Du, Ruotian,Li L,Ji, Jing,et al. Receptor-Ligand Binding: Effect of Mechanical Factors[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 10,2023,24:9062.
APA	Du, Ruotian,李龙,Ji, Jing,&Fan, Yubo.(2023).Receptor-Ligand Binding: Effect of Mechanical Factors.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24,9062.
MLA	Du, Ruotian,et al."Receptor-Ligand Binding: Effect of Mechanical Factors".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24(2023):9062.