The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses

doi:10.3389/fimmu.2020.01420

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses
	Lv, Zhao 3,4,5; Qiu, Limei 3,5; Wang, Weilin 1,2,6; Liu, Zhaoqun 1,2,6; Liu, Qing 3,5; Wang, Lingling 1,2,6; Song, Linsheng 1,2,6
刊名	FRONTIERS IN IMMUNOLOGY
	2020-07-23
卷号	11 页码:22
关键词	Crassostrea gigas integrin family immune function ECM ligand binding functional division and cooperation
ISSN号	1664-3224
DOI	10.3389/fimmu.2020.01420
通讯作者	Qiu, Limei(qiulimei@qdio.ac.cn) ; Song, Linsheng(lshsong@dlou.edu.cn)
英文摘要	Studies on invertebrate immune receptors can provide insights into characteristics specific to innate immune system. Here, eight alpha and three beta integrins are identified from an invertebrate, the Pacific oysterCrassostrea gigas, and their possible immune functions are studied. Oyster alpha/beta integrins exhibit a higher degree of sequence and structural variability than the members fromHomo sapiensandDrosophila melanogaster. The analysis reveals that oyster RGD- and laminin-binding receptor homologs are present in the phylogenetic tree of alpha integrins, but the other six oyster alpha integrins mainly form a species-specific branch; meanwhile, oyster beta integrins are clustered with insect beta integrins but distinct from a member from the molluskBiomphalaria glabrata. Although phylogenetically lacking the important alpha integrin branches of LDV-binding, PS3-type, and alpha I-containing integrins, oyster integrins can bind to most ECM ligands, including RGDCP, LDVCP, GFOGERCP, and laminin protein in a distinct binding pattern. Besides, oyster integrins are distributed in different hemocyte subpopulations, while only specific integrins are selectively involved in hemocyte phagocytosis, migration, and encapsulation, and some of them participate in more than one immune response in a sophisticated pattern. Especially, oyster beta integrins are arranged in the core to mediate complex immune responses, unlike the counterparts in humans that mainly depend on alpha I-containing integrins to incite immune reactions. This study represents the first comprehensive attempt to reveal the structural and evolutionary features of the integrin family and their involvement in cellular immune responses in the non-model invertebrateC. gigasand sheds light on the characteristics specific to the innate immune system in the integrin family.
资助项目	National Natural Science Foundation of China[31530069] ; Research Foundation for Talented Scholars in Dalian Ocean University ; Earmarked Fund from Modern Agro-Industry Technology Research System[CARS-49]
WOS研究方向	Immunology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000560065900001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/168162]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Qiu, Limei; Song, Linsheng
作者单位	1.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol & Dis Contro, Dalian, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao, Peoples R China 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China 6.Dalian Ocean Univ, Liaoning Key Lab Marine Anim Immunol, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Lv, Zhao,Qiu, Limei,Wang, Weilin,et al. The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses[J]. FRONTIERS IN IMMUNOLOGY,2020,11:22.
APA	Lv, Zhao.,Qiu, Limei.,Wang, Weilin.,Liu, Zhaoqun.,Liu, Qing.,...&Song, Linsheng.(2020).The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses.FRONTIERS IN IMMUNOLOGY,11,22.
MLA	Lv, Zhao,et al."The Members of the Highly DiverseCrassostrea gigasIntegrin Family Cooperate for the Generation of Various Immune Responses".FRONTIERS IN IMMUNOLOGY 11(2020):22.