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Broad targeting of triptolide to resistance and sensitization for cancer therapy 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:  Hou, Zhen-yan;  Tong, Xiao-pei;  Peng, Yong-bo;  Zhang, Bi-Kui*;  Yan, Miao*
收藏  |  浏览/下载:48/0  |  提交时间:2019/12/03
ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  
Probucol ameliorates renal injury in diabetic nephropathy by inhibiting the expression of the redox enzyme p66Shc 期刊论文
Redox Biology, 2017, 卷号: 13, 页码: 482-497
作者:  Yang, Shikun;  Zhao, Li;  Han, Yachun;  Liu, Yu;  Chen, Chao
收藏  |  浏览/下载:24/0  |  提交时间:2019/12/03
DN  diabetic nephropathy  ROS  reactive oxygen species  HG  high-glucose  SIRT1  sirtuin-1  Ac-H3  acetyl-histone H3  STZ  streptozotocin  AMPK  AMP-activated protein kinase  ECM  extracellular matrix  Nox2  NADPH oxidase 2  EMT  tubular epithelial-mesenchymal transition  DAPI  4′,6-diamidino-2-phenylindole 9  DHE  dihydroethidium  NDRD  non-diabetic renal disease  H&E  hematoxylin-eosin  PAS  periodic acid-Schiff  PASM  periodic acid-silver methenamine  IHC  immunohistochemistry  MDA  malondialdehyde  ChIP  chromatin immunoprecipitation  TC  total cholesterol  BUN  blood urea nitrogen  FN  fibronectin  HBA1C  glycosylated hemoglobin  Scr  serum creatinine  TG  triglyceride  Probucol  Renal injury  Diabetic nephropathy  p66Shc  
Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages 期刊论文
Journal of Allergy and Clinical Immunology, 2017, 卷号: 140, 期号: 6, 页码: 1550-1561.e8
作者:  Wang, Yi;  Zhu, Jianghui;  Zhang, Lei;  Zhang, Zhijun;  He, Long
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/03
Salt-inducible Kinase (SIK1) regulates HCC progression and WNT/β-catenin activation 期刊论文
Journal of Hepatology, 2016, 卷号: 64, 期号: 5, 页码: 1076-1089
作者:  Qu, Chao;  He, De;  Lu, Xiaoling;  Dong, Lihua;  Zhu, Yuekun
收藏  |  浏览/下载:15/0  |  提交时间:2019/12/03
A novel function of nuclear nonmuscle myosin regulatory light chain in promotion of xanthine oxidase transcription after myocardial ischemia/reperfusion 期刊论文
Free Radical Biology and Medicine, 2015, 卷号: 83, 页码: 115-128
作者:  Zhang, Yi-Shuai;  Liu, Bin;  Luo, Xiu-Ju;  Zhang, Jie-Jie;  Li, Nian-Sheng
收藏  |  浏览/下载:10/0  |  提交时间:2019/12/03
Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma 期刊论文
Cancer Letters, 2015, 卷号: 366, 期号: 1, 页码: 112-122
作者:  Zhang, Xin;  Yang, Xin-Rong;  Sun, Chao;  Hu, Bo;  Sun, Yun-Fan
收藏  |  浏览/下载:14/0  |  提交时间:2019/12/03
HCC  hepatocellular carcinoma  ATO  arsenic trioxide  APL  acute promyelocytic leukemia  PML  promyelocytic leukemia protein  RARα  retinoic acid receptor α  ALDH3A1  aldehyde dehydrogenase 3 family member A1  qRT-PCR  quantitative real-time reverse transcriptase polymerase chain reaction  TMA  tissue microarray  OS  overall survival  TTR  time to recurrence  DMEM  Dulbecco's modified Eagle's medium  CB7  1-[(4-fluorophenyl) sulfonyl]-2-methyl-1H-benzimidazole  siRNA  small interfering RNA  shRNA  small hairpin RNA  GFP  green fluorescent protein  MTT  3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium bromide  ChIP  chromatin immunoprecipitation  ORF  open reading frame  ROS  reactive oxygen species  DCFH-DA  2,7-dichlorfluorescein-diacetate  AFP  α-fetoprotein  ALT  alanine aminotransferase  TTP  time to progression  GO  gene ontology  NFκB  nuclear factor kappa-light-chain-enhancer of activated B cells  Bcl-2  B-cell lymphoma 2  Promyelocytic leukemia protein  Aldehyde dehydrogenase 3 family member A1  Reactive oxygen species  Tumor growth  Drug resistance  
CBP-dependent Wnt/beta-catenin Signaling is Crucial in Regulation of MDR1 Transcription 期刊论文
Current Cancer Drug Targets, 2015, 卷号: 15, 期号: 6, 页码: 519-532
作者:  Xia, Zanxian*;  Guo, Mingquan;  Liu, Han;  Jiang, Luwei;  Li, Qiaoxia
收藏  |  浏览/下载:9/0  |  提交时间:2019/12/03
As a novel p53 direct target, bidirectional gene HspB2/αB-crystallin regulates the ROS level and Warburg effect 期刊论文
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014, 卷号: 1839, 期号: 7, 页码: 592-603
作者:  Liu, Shuang;  Yan, Bin;  Lai, Weiwei;  Chen, Ling;  Xiao, Desheng
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/03
Curcumin Alleviates Neuropathic Pain by Inhibiting p300/CBP Histone Acetyltransferase Activity-Regulated Expression of BDNF and Cox-2 in a Rat Model 期刊论文
PLOS ONE, 2014, 卷号: 9, 期号: 3, 页码: e91303
作者:  Zhu, Xiaoyan;  Li, Qian;  Chang, Ruimin;  Yang, Dong;  Song, Zongbing
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03
Identification of target genes of transcription factor CEBPB in acute promyelocytic leukemia cells induced by all-trans retinoic acid 期刊论文
Asian Pacific Journal of Tropical Medicine, 2013, 卷号: 6, 期号: 6, 页码: 473-480
作者:  Yu, Lei;  Zhang, Yang-De;  Zhou, Jun;  Yao, De-Ming;  Li, Xiang*
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03


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