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科研机构
复旦大学上海医学院 [3]
南华大学 [2]
上海神经科学研究所 [1]
中南大学 [1]
武汉大学 [1]
中国医学科学院 北京... [1]
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期刊论文 [9]
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Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
miR-29b regulates Ang II-induced EMT of rat renal tubular epithelial cells via targeting PI3K/AKT signaling pathway
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 卷号: 42, 期号: 1
作者:
Hu, Hongtao
;
Hu, Shuang
;
Xu, Shen
;
Gao, Yue
;
Zeng, Fang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
epithelial-mesenchymal transition
microRNA-29b
RIF
phosphatidylinositol 3-kinase
protein kinase B
signaling pathway
phosphatase and tensin homolog on chromosome 10
SF1670
Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 卷号: 14, 期号: 4
作者:
Zhou, Hai-Mei
;
Sun, Qin-Xiang
;
Cheng, Yan
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
apoptosis
ovarian cancer
paeonol
phosphatidylinositol-3-kinase/Akt pathway
radiotherapy
vascular endothelial growth factor
MicroRNA-21 promotes phosphatase gene and protein kinase B/ phosphatidylinositol 3-kinase expression in colorectal cancer
期刊论文
WORLD JOURNAL OF GASTROENTEROLOGY, 2016, 卷号: 22, 期号: 24
作者:
Sheng, Wei-Zhong
;
Chen, Yu-Sheng
;
Tu, Chuan-Tao
;
He, Juan
;
Zhang, Bo
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
MicroRNA-21
protein kinase B
Colorectal cancer
phosphatidylinositol 3-kinase
phosphatase and tensin homolog
PI3K/Akt signaling in osteosarcoma
期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 期号: Volume 444, 页码: 182-192
作者:
Zhang, Jian
;
Yu, Xiao-Hua
;
Yan, Yi-Guo
;
Wang, Cheng
;
Wang, Wen-Jun*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/27
OS
osteosarcoma
PI3K
phosphatidylinositol 3-kinase
PTEN
phosphatase and tensin homolog
mTOR
mammalian target of rapamycin
RTKs
receptor tyrosine kinases
PDGFR
platelet-derived growth factor receptor
IGF1R
insulin-like growth factor 1 receptor
PIP2
phosphatidylinositol 4,5-biphosphate
PIP3
phosphatidylinositol 3,4,5-triphosphate
PDK1
phosphoinositide-dependent kinase 1
PH
pleckstrin homology
CDK
cyclin-dependent kinase
NF-κB
nuclear factor-κB
MDM2
Murine double minute 2
Rb
retinoblastoma
CSCs
cancer stem cells
CXCR7
CXC chemokine receptor 7
GA
gallic acid
miRNAs
microRNAs
TNF
tumor necrosis factor
HIF-1
hypoxia-inducible factor-1
ET-1
endothelin-1
ETAR
endothelin A receptor
MMP
matrix metalloproteinase.
OS
PI3K
Akt
PTEN
mTOR
MicroRNAs in osteosarcoma
期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 页码: 9-17
作者:
Zhang, Jian
;
Yan, Yi-Guo
;
Wang, Cheng
;
Zhang, Shu-Jun
;
Yu, Xiao-Hua*
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/12/27
OS
osteosarcoma
miRNAs
microRNAs
CSCs
cancer stem cells
RNA pol
RNA polymerase
DGCR8
DiGeorge syndrome critical gene 8
RISC
RNA-induced silencing complex
Exp 5
exportin 5
Ago
argonaute
MREs
miRNA recognition elements
APE1
apurinic/apyrimidinic endonuclease 1
MDM
murine double minute
TP53
tumor suppressor p53
mTOR
mammalian target of rapamycin
Eag1
ether à go-go 1
PI3K
phosphatidylinositol-3-kinase
PTEN
phosphatase and tensin homolog deleted on chromosome ten
Hsp90B1
heat shock protein 90B1
BMP2
bone morphogenetic protein 2
IGF1R
insulin-like growth factor 1 receptor
FAK
phospho-Akt and focal adhesion kinase
LPAATβ
lysophosphatidic acid acyltransferase β
HMGB1
high-mobility group box 1
FASN
fatty acid synthase
LZTS1
leucine zipper putative tumor suppressor 1
MMP
matrix metalloproteinase
LNA
locked nucleic acid
DATS
diallyl trisulfide
miRNAs
OS
TP53
Notch
Chemoresistance
Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line lapatinib plus paclitaxel or paclitaxel alone
期刊论文
BREAST CANCER RESEARCH, 2014, 卷号: 16, 期号: 4
作者:
Xu, Binghe
;
Guan, Zhongzhen
;
Shen, Zhenzhou
;
Tong, Zhongshen
;
Jiang, Zefei
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/19
Association of phosphatase and tensin homolog low and phosphatidylinositol 3-kinase catalytic subunit alpha gene mutations on outcome in human epidermal growth factor receptor 2-positive metastatic breast cancer patients treated with first-line l
期刊论文
2014, 卷号: 16, 期号: 4
作者:
Xu, Binghe
;
Guan, Zhongzhen
;
Shen, Zhenzhou
;
Tong, Zhongshen
;
Jiang, Zefei
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury
期刊论文
JOURNAL OF NEUROCHEMISTRY, 2006, 卷号: 98, 期号: 6, 页码: 1886-1898
Zhang, Quan-Guang
;
Wang, Xiao-Tian
;
Han, Dong
;
Yin, Xiao-Hui
;
Zhang, Guang-Yi
;
Xu, Tian-Le
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2012/07/23
Akt
hippocampus
mixed-lineage kinase 3
neuronal death
orthovanadate
Rac1
TRANSIENT FOREBRAIN ISCHEMIA
MIXED LINEAGE KINASE-3
BINDING PROTEINS RAC1
C-JUN
IN-VIVO
NEURONAL APOPTOSIS
CEREBRAL-ISCHEMIA
3-KINASE PATHWAY
CELL-SURVIVAL
SMALL GTPASES
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