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科研机构
上海药物研究所 [10]
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期刊论文 [10]
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2022 [1]
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Intestinal farnesoid X receptor signaling controls hepatic fatty acid oxidation
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2022, 卷号: 1867, 期号: 2, 页码: 13
作者:
Lu, Dasheng
;
Liu, Yameng
;
Luo, Yuhong
;
Zhao, Jie
;
Feng, Chao
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2022/01/18
Fatty acid oxidation
Acylcarnitines
FXR
FGF15/19
PGC1 alpha
Transcriptomics
Metabolomics
Design, synthesis and biological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 3, 页码: 781-794
作者:
Wu, Xiaowei
;
Dai, Mengdi
;
Cui, Rongrong
;
Wang, Yulan
;
Li, Chunpu
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
Tyrosine kinase
Covalent FGFR inhibitors
Virtual screening
Pyrazolo[3,4-d] pyridazinone
Structure-activity relationships
Antitumor efficacy
c11anovelfibroblastgrowthfactorreceptor1fgfr1inhibitorsuppressesbreastcancermetastasisandangiogenesis
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 6, 页码: 823
作者:
Chen Zhuo
;
Tong Linjiang
;
Tang Baiyou
;
Liu Hongyan
;
Wang Xin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
SELECTIVE INHIBITOR
THERAPEUTIC TARGET
DISCOVERY
ACTIVATION
EXPRESSION
PATHWAY
POTENT
C11
FGFR1 inhibitor
antitumor
breast cancer
metastasis
angiogenesis
The secretome engages STAT3 to favor a cytokine-rich microenvironment in mediating acquired resistance to FGFR inhibitors
期刊论文
Molecular cancer therapeutics, 2018, 卷号: 145, 页码: 817-842
作者:
Wang, Xinyi
;
Ai, Jing
;
Liu, Hongyan
;
Peng, Xia
;
Chen, Hui
收藏
  |  
浏览/下载:135/0
  |  
提交时间:2019/01/08
1,4-Diaryl-2-azetidinone
Combretastatin A-4
Tubulin polymerization
Antitumor
C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Chen, Zhuo
;
Tong, Lin-Jiang
;
Tang, Bai-You
;
Liu, Hong-Yan
;
Wang, Xin
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2019/01/08
A Novel 2-Phenylamino-Quinazoline-Based Compound Expands the Neural Stem Cell Pool and Promotes the Hippocampal Neurogenesis and the Cognitive Ability of Adult Mice
期刊论文
STEM CELLS, 2018, 卷号: 36, 期号: 8, 页码: 1273-1285
作者:
Lu, Hui
;
Cheng, Gang
;
Hong, Feng
;
Zhang, Lei
;
Hu, Youhong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Neural stem cells
Notch signaling pathway
Hes5
Adult hippocampal neurogenesis
Learning and memory
2-phenylamino-quinazoline
Effects of Pro-Arg, a Novel Dipeptide Derived from Protamine Hydrolysate on H2O2-Induced Oxidative Stress in Human Diploid Fibroblasts
期刊论文
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2009, 卷号: 32, 期号: 3, 页码: 389-393
作者:
Wang, Yonggang
;
Zhu, Fengrong
;
Chen, Jie
;
Han, Fusen
;
Wang, Heyao
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
antioxidant dipeptide
human diploid fibroblast
reactive oxygen species
Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential
期刊论文
MOLECULAR CANCER RESEARCH, 2006, 卷号: 4, 期号: 11, 页码: 843-849
作者:
Zhuang, Zhi-Gang
;
Di, Gen-Hong
;
Shen, Zhen-Zhou
;
Ding, Jian
;
Shao, Zhi-Ming
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Philinopside A, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2005, 卷号: 114, 期号: 6, 页码: 843-853
作者:
Tong, YG
;
Zhang, XW
;
Tian, F
;
Yi, YH
;
Xu, QZ
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
philinopside A
receptor tyrosine kinase
tumor angiogenesis
Progress in the design of matrix metalloproteinase inhibitors
期刊论文
PROGRESS IN CHEMISTRY, 2001, 卷号: 13, 期号: 4, 页码: 283-293
作者:
Cheng, F
;
Liu, H
;
Luo, XM
;
Jiang, HL
;
Shen, JK
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
matrix metalloproteinase
inhibitor
substrate-based design
structure-based design
combinatorial chemistry
SAR-by-NMR
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