Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential

doi:10.1158/1541-7786.MCR-06-0118

	Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential
	Zhuang, Zhi-Gang ; Di, Gen-Hong ; Shen, Zhen-Zhou ; Ding, Jian; Shao, Zhi-Ming
刊名	MOLECULAR CANCER RESEARCH
	2006-11
卷号	4 期号:11 页码:843-849
ISSN号	1541-7786
DOI	10.1158/1541-7786.MCR-06-0118
文献子类	Article
英文摘要	LKB1 (also known as STK11) is a recently identified tumor suppressor gene whose mutation can lead to Peutz-Jeghers syndrome, which is characterized by gastrointestinal polyps and cancers of different organ systems. Approximately 30% of sporadic breast cancer samples express low levels of LKB1. This suggests that the LKB1 gene may be related to the tumorigenesis of breast cancer. We reintroduced LKB1 into MDA-MB-435 breast cancer cells that lack the LKB1 gene to investigate how overexpression of LKB1 affects tumor invasiveness and metastasis. Overexpression of the LKB1 protein in breast cancer cells resulted in significant inhibition of in vitro invasion. In vivo, LKB1 expression reduced tumor growth in the mammary fat pad, microvessel density, and lung metastasis. LKB1 overexpression was associated with down-regulation of matrix metal loproteinase-2, matrix metal loproteinase-9, vascular endothelial growth factor, and basic fibroblast growth factor mRNA and protein levels. Overexpression of the LKB1 protein in human breast cancer is significantly associated with a decrease in microvessel density. Our results indicate that LKB1 plays a negative regulatory role in human breast cancer, a finding that may lead to a new therapeutic strategy.
WOS关键词	PEUTZ-JEGHERS-SYNDROME ; MICROVESSEL DENSITY ; CARCINOMA ; KINASE ; INVASIVENESS ; MUTATIONS ; PTEN ; VEGF
WOS研究方向	Oncology ; Cell Biology
语种	英语
出版者	AMER ASSOC CANCER RESEARCH
WOS记录号	WOS:000242155300005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/273460]
专题	中国科学院上海药物研究所
通讯作者	Shao, Zhi-Ming
作者单位	1.Fudan Univ, Breast Canc Inst, Canc Hosp Canc Inst, Dept Breast Surg, Shanghai 200032, Peoples R China 2.Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China 3.Chinese Acad Sci, Shanghai Matern & Infant Hlth Hosp, Shanghai 200031, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China
推荐引用方式 GB/T 7714	Zhuang, Zhi-Gang,Di, Gen-Hong,Shen, Zhen-Zhou,et al. Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential[J]. MOLECULAR CANCER RESEARCH,2006,4(11):843-849.
APA	Zhuang, Zhi-Gang,Di, Gen-Hong,Shen, Zhen-Zhou,Ding, Jian,&Shao, Zhi-Ming.(2006).Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential.MOLECULAR CANCER RESEARCH,4(11),843-849.
MLA	Zhuang, Zhi-Gang,et al."Enhanced expression of LKB1 in breast cancer cells attenuates angiogenesis, invasion, and metastatic potential".MOLECULAR CANCER RESEARCH 4.11(2006):843-849.