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科研机构
西安交通大学 [3]
吉林大学白求恩第一医... [3]
中国医学科学院 北京... [3]
复旦大学上海医学院 [2]
上海药物研究所 [1]
四川大学 [1]
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期刊论文 [16]
学位论文 [2]
会议论文 [1]
发表日期
2018 [19]
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Inhibiting mechanism of small molecule toward the p53-MDM2 interaction: A molecular dynamic exploration
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 4, 页码: 1763-1777
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Pang, Laixue
;
Zhu, Weiliang
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
hydrophobic contact scanning
MM-GBSA
p53-MDM2 interaction
principal component analysis
solvated interaction energy
The Real-Time Detection of Mouse Double Minute-2 mRNA Expression in Living Cells with the Gold Nanoparticle
期刊论文
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2018, 卷号: 8, 期号: 1
作者:
Xu, Ruisi
;
Li, Kai
;
Li, Changfeng
;
Ding, Meng
;
Zhang, Ying
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Mdm2 mRNA
Gold Nanoparticles
Beacon
Variation
Imaging
Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 506, 期号: 3
作者:
Chen, Geng
;
Zhou, Tong
;
Liu, Ying
;
Yu, Zhenxiang
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
TRIM65
MDM2
p53
Lung cancer
Therapeutics
Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells
期刊论文
Biochemical and Biophysical Research Communications, 2018, 卷号: 506, 期号: 3
作者:
Geng Chen
;
;
Tong Zhou
;
;
Ying Liu
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2019/12/05
TRIM65
MDM2
P53
Lung cancer
Therapeutics
MDM2 controls NRF2 antioxidant activity in prevention of diabetic kidney disease
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2018, 卷号: 1865, 期号: 8
作者:
Guo, Weiying
;
Tian, Dan
;
Jia, Ye
;
Huang, Wenlin
;
Jiang, Mengnan
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  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
Diabetes
Diabetic nephropathy
Nrf2
Oxidative stress
P53
Nutlin-3a as a novel anticancer agent for adrenocortical carcinoma with CTNNB1 mutation
期刊论文
CANCER MEDICINE, 2018, 卷号: 7, 期号: 4
作者:
Hui, Wen
;
Liu, Shenghua
;
Zheng, Jie
;
Fang, Zujun
;
Ding, Qiang
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
Adrenocortical carcinoma
CTNNB1
MDM2
Nutlin-3a
TP53
Treating hepatocellular carcinoma metastasis and overcoming chemoresistance through inhibiting the MDM2 oncogene
会议论文
作者:
Wang, Wei
;
Hu, Bo
;
Qin, Jiang-Jiang
;
Cheng, Jianwen
;
Li, Xin
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  |  
浏览/下载:11/0
  |  
提交时间:2019/12/05
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
血流剪应力调节 ACE2 泛素化的机制
学位论文
2018
作者:
史欣兴
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/11/26
血管紧张素转化酶 2
动脉粥样硬化
内皮细胞
MDM2
腺苷酸活化蛋白激酶
EGFR罕见突变非小细胞肺癌患者的生存分析及 PD-1/PD-L1/MDM2的表达及意义
学位论文
2018
作者:
牛文霞
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/11/26
非小细胞肺癌
EGFR罕见突变
PD-1
PD-L1
MDM2
生存分析
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