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上海药物研究所 [34]
复旦大学上海医学院 [10]
兰州大学 [6]
武汉大学 [5]
山东大学 [4]
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期刊论文 [104]
学位论文 [2]
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2016 [107]
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Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2016, 卷号: 30, 期号: 1-12, 页码: 1189-1200
作者:
Liu, HL
;
Han, R
;
Li, JZ
;
Liu, HX
;
Zheng, LF
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/05/09
R-bicalutamide
Androgen receptor antagonist
Molecular dynamics simulations
MM-GBSA
Drug-resistant mechanism
Staurosporine as an agonist for induction of GLUT4 translocation, identified by a pH-sensitive fluorescent IRAP-mOrange2 probe
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 卷号: 480, 期号: 4, 页码: 534-538
作者:
Li, Yufeng
;
Zheng, Li
;
Wang, Dan
;
Zhang, Xiang
;
Li, Jia
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Diabetes
pH-sensitive fluorescent probe
GLUT4 translocation
Staurosporine
Insulin additive analogue
An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain
期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:
Yin, Yanting
;
Zhou, X. Edward
;
Hou, Li
;
Zhao, Li-Hua
;
Liu, Bo
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
GLP-1R
class B GPCR
intrinsic agonist
glucagon-like peptide-1
exendin-4
BETP
CXCR4 ACTIVATION PROMOTES DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO NEURAL STEM CELLS
期刊论文
NEUROSCIENCE, 2016, 卷号: 337, 页码: 88-97
作者:
Zhang, Lijun
;
Hua, Qiuhong
;
Tang, Kaiyi
;
Shi, Changjie
;
Xie, Xin
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
human embryonic stem cell
neural stem/precursor cell
neural differentiation
chemokine receptor
CXCR4
SDF-1
Insight into the Mechanisms of Combined Toxicity of Single-Walled Carbon Nanotubes and Nickel Ions in Macrophages: Role of P2X(7) Receptor
期刊论文
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2016, 卷号: 50, 期号: 22, 页码: 12473-12483
作者:
Cui, Xuejing
;
Wan, Bin
;
Guo, Liang-Hong
;
Yang, Yu
;
Ren, Xiaomin
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2017/03/27
CgA1AR-1 acts as an alpha-1 adrenergic receptor in oyster Crassostrea gigas mediating both cellular and humoral immune response
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2016, 卷号: 58, 页码: 50-58
作者:
Liu, Zhaoqun
;
Zhou, Zhi
;
Wang, Lingling
;
Qiu, Limei
;
Zhang, Huan
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2017/03/21
Crassostrea gigas
Norepinephrine
Alpha-1 adrenergic receptor
TNF pathway
Immune regulation
Evaluation and characterization of thyroid-disrupting activities in soil samples along the Second Songhua River, China
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2016, 卷号: 133, 期号: 0, 页码: 475-480
作者:
Kong, Dongdong
;
Wang, Yafei
;
Wang, Jinsheng
;
Teng, Yanguo
;
Li, Na
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2017/03/29
In vitro bioassay
Thyroid receptor
Soil sample
Thyroid-disrupting chemicals
kappa Opioid receptor activation in different brain regions differentially modulates anxiety-related behaviors in mice
期刊论文
NEUROPHARMACOLOGY, 2016, 卷号: 110, 页码: 92-101
作者:
Wang, Yu-Jun
;
Hang, Ai
;
Lu, Yu-Chen
;
Long, Yu
;
Zan, Gui-Ying
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/01/08
kappa Opioid receptor
pERK1/2
Region-specific
Dual effects
Anxiety
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective alpha(1A)-Adrenoceptor Antagonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 20, 页码: 9489-9502
作者:
Guo, Diliang
;
Li, Jing
;
Lin, Henry
;
Zhou, Yu
;
Chen, Ying
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
Crystal Structure of the Human Cannabinoid Receptor CB1
期刊论文
CELL, 2016, 卷号: 167, 期号: 3, 页码: 750-+
作者:
Hua, Tian
;
Vemuri, Kiran
;
Pu, Mengchen
;
Qu, Lu
;
Han, Gye Won
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
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