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CORC

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A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua
收藏  |  浏览/下载：34/0  |  提交时间：2021/08/17
Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2020, 卷号: 191, 页码: 8
作者:  Zhang, Mengqi;  Liu, Haiming;  He, Jiajin;  Gui, Yuzhou;  Qian, Hongjie
收藏  |  浏览/下载：29/0  |  提交时间：2020/12/24
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei;  Xu, Ye-chun
收藏  |  浏览/下载：68/0  |  提交时间：2020/12/24
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan
收藏  |  浏览/下载：53/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei
收藏  |  浏览/下载：39/0  |  提交时间：2020/07/01
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Z (Wang, Zhen)[ 1 ];  Jiang, XR (Jiang, Xiangrui)[ 1 ];  Zhang, XL (Zhang, Xianglei)[ 1,2 ];  Tian, GH (Tian, Guanghui)[ 3 ];  Yang, RL (Yang, Rulei)[ 3 ]
收藏  |  浏览/下载：137/0  |  提交时间：2019/06/28
The Clinical Effects of Sildenafil for Erection in Patients after Kidney Transplantation: A Meta-Analysis 期刊论文
NEPHRON, 2019, 卷号: 141, 期号: 1
作者:  Ma, Fu-Zhe;  Liu, Ling-Yun;  Sun, Tao;  Liu, Yang;  Sun, Yan-Yan
收藏  |  浏览/下载：23/0  |  提交时间：2019/12/05
N-Acetylcysteine potentiates the haemodynamic-improving effect of sildenafil in a rabbit model of acute pulmonary thromboembolism via the p38 MAPK pathway. 期刊论文
Clinical and experimental pharmacology & physiology, 2019, 卷号: 46, 页码: 163-172
作者:  Zhang Ruipeng;  Wang Yang;  Pan Longfei;  Tian Hongyan
收藏  |  浏览/下载：3/0  |  提交时间：2019/11/19
Sildenafil improves blood perfusion in steroid-induced avascular necrosis of femoral head in rabbits via a protein kinase G-dependent mechanism 期刊论文
ACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICA, 2017, 卷号: 51, 页码: 398-403
作者:  Song, Qichun;  Ni, Jianlong;  Jiang, Hongyuan;  Shi, Zhibin
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/26
Sildenafil suppresses the proliferation and enhances the apoptosis of hemangioma endothelial cells 期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 卷号: 13, 期号: 6, 页码: 2645-2650
作者:  He, Xiaopo;  Liu, Yiran;  Li, Kai;  Yang, Aijun;  Wang, Rui
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/12

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