×
验证码:
换一张
忘记密码?
记住我
CORC
首页
科研机构
检索
知识图谱
申请加入
托管服务
登录
注册
在结果中检索
科研机构
上海药物研究所 [34]
吉林大学白求恩第一... [22]
复旦大学上海医学院 [11]
山东大学 [8]
四川大学 [5]
中国医学科学院 北京... [5]
更多...
内容类型
期刊论文 [105]
专利 [21]
学位论文 [4]
会议论文 [1]
发表日期
2022 [1]
2021 [1]
2020 [1]
2019 [8]
2018 [20]
2017 [13]
更多...
学科主题
Chemistry [3]
药物化学 [3]
Pharmacolo... [2]
Materials ... [1]
Physics [1]
general & ... [1]
更多...
×
知识图谱
CORC
开始提交
已提交作品
待认领作品
已认领作品
未提交全文
收藏管理
QQ客服
官方微博
反馈留言
浏览/检索结果:
共131条,第1-10条
帮助
已选(
0
)
清除
条数/页:
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
排序方式:
请选择
发表日期升序
发表日期降序
提交时间升序
提交时间降序
题名升序
题名降序
作者升序
作者降序
Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists
期刊论文
PHARMACEUTICALS, 2022, 卷号: 15
作者:
Sun, Lei
;
Zheng, Zhi-Ming
;
Shao, Chang-Sheng
;
Zhang, Zhi-Yong
;
Li, Ming-Wei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/12/22
glucagon-like peptide-1
GLP-1 receptor agonist
functional protein design
molecular dynamics simulation
long-acting antihyperglycemic
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Li, Teng-teng
;
Peng, Cheng
;
Wang, Ji-qiu
;
Xu, Zhi-jian
;
Su, Ming-bo
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
DPP4
distal mutation
enzymatic activity
molecular dynamics simulation
structure-function mechanism
Dipeptidyl peptidase 4 inhibitor sitagliptin protected against dextran sulfate sodium-induced experimental colitis by potentiating the action of GLP-2
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Ning, Meng-meng
;
Yang, Wen-ji
;
Guan, Wen-bo
;
Gu, Yi-pei
;
Feng, Ying
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/07/01
ulcerative colitis
dextran sulfate sodium
dipeptidyl peptidase 4
sitagliptin
glucagon-like peptide-2
GLP-2(3-33)
apoptosis
proliferation
Saxagliptin alters bile acid profiles and yields metabolic benefits in drug-naive overweight or obese type 2 diabetes patient
期刊论文
JOURNAL OF DIABETES, 2019, 页码: 11
作者:
Li, Wen
;
Liu, Ruixin
;
Li, Xuelin
;
Tao, Bei
;
Zhai, Nan
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2019/12/02
bile acids
dipeptidyl peptidase-4 inhibitor
obesity
saxagliptin
type 2 diabetes
Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 511, 期号: 2, 页码: 387-393
作者:
Zhang, Hanyan
;
Sun, Dandan
;
Wang, Guanzhen
;
Cui, Shichao
;
Field, Robert A.
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
DPP4
Alogliptin
Liver fibrosis
Hepatic stellate cell
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 5, 页码: 2348-2361
作者:
Li, Shiliang
;
Qin, Chun
;
Cui, Shichao
;
Xu, Hongling
;
Wu, Fangshu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
Origin and evolution of pathogenic coronaviruses
期刊论文
Nature reviews microbiology, 2019, 卷号: 17, 期号: 3, 页码: 181-192
作者:
Cui, Jie
;
Li, Fang
;
Shi, Zheng-Li
收藏
  |  
浏览/下载:214/0
  |  
提交时间:2019/05/08
Predictive significance of serum dipeptidyl peptidase-IV in papillary thyroid carcinoma
期刊论文
CANCER BIOMARKERS, 2019, 卷号: 24, 期号: 1
作者:
Xu, Dahai
;
Zhang, Nan
;
Cong, Xiaoqiang
;
Zhou, Dan
;
Su, Chang
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/05
Dipeptidyl peptidase-IV
CD26
papillary thyroid carcinoma
structurally persistent
recurrent disease
Efficacy and short-term side effects of sitagliptin, vildagliptin and saxagliptin in Chinese diabetes: a randomized clinical trial
期刊论文
ENDOCRINE CONNECTIONS, 2019, 卷号: 8, 期号: 4, 页码: 318-325
作者:
Zhou, Xiao-jun
;
Ding, Lin
;
Liu, Jia-xin
;
Su, Le-qun
;
Dong, Jian-jun
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/12/11
dipeptidyl peptidase-4 inhibitors
hemoglobin A1c
Chinese
diabetes
Vildagliptin reduces lipid levels possibly by mechanisms associated with HMGCR and CYP7A1
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2019, 卷号: 12, 期号: 9, 页码: 11657-11665
作者:
Du, Wenhua
;
Ma, Xiaoqing
;
Shao, Shanshan
;
Yu, Chunxiao
;
Zhao, Lifang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/11
Dipeptidyl peptidase 4 (DPP-4) inhibitors
vildagliptin
lipid
liver
damage
©版权所有 ©2017 CSpace - Powered by
CSpace