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Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14
作者:
Zhang, Chun
;
Sun, Yi-Tao
;
Gao, Li-Xin
;
Feng, Bo
;
Yan, Xue
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2022/01/18
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105
作者:
Yu Lijie
;
Feng Bo
;
Wang Zhijia
;
Gao Lixin
;
Zhang Chun
收藏
  |  
浏览/下载:187/0
  |  
提交时间:2021/11/04
5-phenyl-1,3,4-thiadiazole derivatives
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)
inhibitors
structure-activity relationships
Transcriptomic analysis of glioblastoma multiforme providing new insights into GPR17 signaling communication
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 页码: 14
作者:
Mutharasu, Gnanavel
;
Murugesan, Akshaya
;
Konda Mani, Saravanan
;
Yli-Harja, Olli
;
Kandhavelu, Meenakshisundaram
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  |  
浏览/下载:23/0
  |  
提交时间:2020/12/10
GPR17
signaling networks
glioblastoma multiforme
RNA-Seq
protein–
protein interface
kinases
Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 31, 页码: 10842-10856
作者:
Liu, Wen
;
Yin, Ye
;
Wang, Meijing
;
Fan, Ting
;
Zhu, Yuyu
收藏
  |  
浏览/下载:182/0
  |  
提交时间:2020/12/24
Src homology 2 domain containing tyrosine phosphatase-2 (SHP2)
hepatic steatosis
insulin resistance
caspase-1
interleukin 18 (IL-18)
fatty liver
metabolic disorder
inflammation
cytokine signaling
caspase 1 (CASP1)
tyrosine-protein phosphatase (tyrosine phosphatase)
macrophage
Molecular cloning, characterization and expression profiles of CD2AP in Nile tilapia (Oreochromis niloticus) responding to Streptococcus agalactiae infection and interaction with CD2 cytoplasmic segment
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2020, 卷号: 101, 页码: 205-215
作者:
Li, Yuan
;
Wang, Bei
;
Wang, Zhi-wen
;
Huang, Yu
;
Jian, Ji-chang
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2020/09/24
CD2-associated protein
Nile tilapia
CD2
Immune response
T cells activation
Streptococcus agalactiae
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XIV. Structurally diverse terpenoids from the twigs and needles of the endangered plant Picea brachytyla
期刊论文
PHYTOCHEMISTRY, 2020, 卷号: 169, 页码: 11
作者:
Jiang, Wei
;
Xiong, Juan
;
Zang, Yi
;
Li, Junmin
;
Osman, Ezzat E. A.
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2020/07/01
Picea brachytyla (Franch.) E.Pritz.
Pinaceae
Endangered plant
Terpenoids
Brachytylins
ATP citrate lyase (ACL)
SHP2 tyrosine phosphatase
Solution NMR structure and ligand identification of human Gas7 SH3 domain reveal a typical SH3 fold but a non-canonical ligand-binding mode
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 516, 期号: 4, 页码: 1190-1195
作者:
Nie, Yao
;
Zhu, Jiang
;
Ramelot, Theresa A.
;
Kennedy, Michael A.
;
Liu, Maili
收藏
  |  
浏览/下载:79/0
  |  
提交时间:2019/10/14
Growth arrest specific 7
Src homology 3
NMR structure
Praline-rich
Phage display
SHIP1 inhibits cell growth, migration, and invasion in non-small cell lung cancer through the PI3K/AKT pathway
期刊论文
ONCOLOGY REPORTS, 2019, 卷号: 41, 期号: 4
作者:
Fu, Qiaofen
;
Huang, Yuhui
;
Ge, Chunlei
;
Li, Zhen
;
Tian, Hui
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/04
Src homology 2-containing inositol-5 '-phosphatase 1
non-small cell lung cancer
phosphoinositide 3-kinase/AKT
epithelial-mesenchymal transition
石斑鱼干扰素信号通路关键基因STAT1a和MAVS在病毒感染过程中的作用机制
学位论文
: 南海海洋研究所, 2018
作者:
张竞成
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  |  
浏览/下载:76/0
  |  
提交时间:2019/09/11
石斑鱼,EcSTAT1a,EcMAVS,病毒复制
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