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科研机构
上海药物研究所 [20]
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期刊论文 [20]
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2021 [1]
2020 [3]
2019 [3]
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Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer
期刊论文
NANO TODAY, 2021, 卷号: 36, 页码: 12
作者:
Zhou, Fengqi
;
Gao, Jing
;
Xu, Zhiai
;
Li, Tianliang
;
Gao, Ang
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/06/11
Tumor microenvironment
Prodrug nanovesicles
Cancer immunotherapy
Immunogenic cell death
Adaptive immune resistance
Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
He, Zhi-di
;
Zhang, Meng
;
Wang, Yong-hui
;
He, Yang
;
Wang, Hai-rui
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2021/05/24
tumor-targeted delivery
immunogenic cell death
PD-1
PD-L1 blockade
tumor immune microenvironment
irinotecan
JQ1
immune checkpoint
Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells (vol 37, pg 405, 2015)
期刊论文
BIOMATERIALS, 2020, 卷号: 263, 页码: 1
作者:
Sun, Rong
;
Liu, Yang
;
Li, Shi-Yong
;
Shen, Song
;
Du, Xiao-Jiao
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  |  
浏览/下载:90/0
  |  
提交时间:2020/12/21
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:85/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
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  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-A beta Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
期刊论文
MOLECULES, 2019, 卷号: 24, 期号: 14, 页码: 21
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Wang, Yin-Yin
;
Tao, Hong-Rui
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  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
selective BChE inhibitor
virtual screening
structural optimization
molecular dynamics
anti-A beta aggregation
Discovery of new multifunctional selective acetylcholinesterase inhibitors: structure-based virtual screening and biological evaluation
期刊论文
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 2019, 卷号: 33, 期号: 5, 页码: 521-530
作者:
Jiang, Cheng-Shi
;
Ge, Yong-Xi
;
Cheng, Zhi-Qiang
;
Song, Jia-Li
;
Wang, Yin-Yin
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/07/01
AChE inhibitor
Pharmacophore model
Molecular docking
Anti-A aggregation
Neuroprotective activity
The discovery of novel small molecular CXCR2 antagonist by using ligand-based pharmacophore model
期刊论文
CANCER RESEARCH, 2018, 卷号: 78, 期号: 13, 页码: 2
作者:
Huang, Wen-Hai
;
Wang, Zhi-Long
;
Che, Jin-Xin
;
Sheng, Hai-Chao
;
Huang, Feng
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
Bicyclo[2.2.1]heptane containing N,N-diarylsquaramide CXCR2 selective antagonists as anti-cancer metastasis agents
期刊论文
RSC ADVANCES, 2018, 卷号: 8, 期号: 20, 页码: 11061-11069
作者:
Che, Jin-Xin
;
Wang, Zhi-Long
;
Dong, Xiao-Wu
;
Hu, You-Hong
;
Xie, Xin
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
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