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Broad targeting of triptolide to resistance and sensitization for cancer therapy 期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:  Hou, Zhen-yan;  Tong, Xiao-pei;  Peng, Yong-bo;  Zhang, Bi-Kui*;  Yan, Miao*
收藏  |  浏览/下载:50/0  |  提交时间:2019/12/03
ABC  ATP-binding cassette  AKT  V-Akt murine thymoma viral oncogene homolog  ALDH1  aldehyde dehydrogenase 1  AR  androgen receptor  Bad  Bcl-2-associated death promoter  Bak  Bcl-2 homologous antagonist killer  Bax  Bcl-2-associated X protein  Bcl-2  B-cell lymphoma  Bcl-xL  Bcl-extra large  Bcl-xs  Bcl-extra short  BCRP  breast cancer resistance protein  Bid  BH3 interacting domain death agonist  Bik  Bcl-2-interacting killer  BNIP3  Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3  CAF  cancer-associated fibroblast  CAIX  carbonic anhydrase IX  cFLIP  cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein  ChIP  chromatin immunoprecipitation  CI  Combination Index  cIAP1/2  cellular IAP1/2  CML  chronic myelogenous leukemia  CSC  cancer stem cell  DISC  death-inducing signaling complex  DR  death receptor  DRI  Dose Reduction Index  ECM  extracellular matrix  EMT  epithelial-mesenchymal transition  EpCAM  epithelial cell adhesion molecule  GLUT  glucose transporter  GSK3β  glycogen synthase kinase-3β  HIF-1  hypoxia inducible factor-1  HSF1  heat shock factor 1  HSP  heat shock protein  IAP  inhibitor of apoptosis protein  JNK  c-JUN N-terminal kinase  MAPK  mitogen-activated protein kinase  Mcl-1  myeloid leukemia cell differentiation protein  MDM2  murine double minute 2  MDR  multidrug resistance  MKP  MAPK phosphatase  MRP1  multidrug resistance protein 1  NF-κB  nuclear factor-kappaB  pAkt  phosphor-Akt  PARP  poly ADP-ribose polymerase  P-gp  P-glycoprotein  PI3K-PTEN  phosphatidylinositol 3-kinase-phosphatase and tensin homolog  PKC  phosphorylated at Ser9 by protein kinase C  pp2A  protein phosphatase 2A  REST  repressor element-1 silencing transcription factor  SAR  structure-activity relationship  TAM  tumor-associated macrophage  TFIIH  transcription factor IIH  TKI  tyrosine kinase inhibitor  TM  tumor-microenvironment  TRAIL/Apo-2L  TNF-related apoptosis-inducing ligand  tRXRα  the N-terminal truncated form of the nuclear retinoid X receptor-α  TWHF  Tripterygium wilfordii Hook F  VEGF  vascular endothelial growth factor  XIAP  X-linked IAP  XPB  xerodermapigmentosum group B protein  Triptolide  Antineoplastic  Resistance  Sensitization  Mechanism  
MDM2 promotes rheumatoid arthritis via activation of MAPK and NF-κB 期刊论文
International Immunopharmacology, 2016, 卷号: 30, 页码: 69-73
作者:  Zhang, Lin;  Luo, Jing;  Wen, Hongyan;  Zhang, Tingting;  Zuo, Xiaoxia*
收藏  |  浏览/下载:1/0  |  提交时间:2019/12/03
MicroRNA-340 inhibits prostate cancer cell proliferation and metastasis by targeting the MDM2-p53 pathway 期刊论文
Oncology Reports, 2016, 卷号: 35, 期号: 2, 页码: 887-895
作者:  Huang, Kai;  Tang, Yuxin*;  He, Leye;  Dai, Yingbo
收藏  |  浏览/下载:1/0  |  提交时间:2019/12/03
Renoprotective approaches and strategies in acute kidney injury 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 163, 页码: 58-73
作者:  Yang, Yuan;  Song, Meifang;  Liu, Yu;  Liu, Hong;  Sun, Lin
收藏  |  浏览/下载:20/0  |  提交时间:2019/12/03
ACTH  Adrenocorticotropic hormone  AIF  Apoptosis inducing factor  AKI  Acute kidney injury  BMSC  Bone marrow derived stem cells  CIN  Contrast-induced nephropathy  COMP-Ang1  Cartilage oligomeric matrix protein-angiopoietin-1  CysLT1R  Cysteinyl leukotriene-1 receptor  DMARD  Disease-modifying antirheumatic drugs  eNOS  Endothelial nitric oxide synthase  eEPCs  Endothelial progenitor cells  HDAC  Histone deacetylase  HSPC  Hematopoietic stem and progenitor cells  IRI  Ischemia–reperfusion injury  ICAM-1  Intercellular adhesion molecule-1  JNK  c-Jun N-terminal kinase  KIF3B  Kinesin family member 3B  KIM-1  Kidney injury molecule 1  MAPK  Mitogen-activated protein kinase  MCP-1  Monocyte chemotactic protein-1  α-MSH  Alpha-melanocyte-stimulating hormone  MFG-E8  Milk fat globule-epidermal growth factor-factor VIII  MPT  Mitochondrial permeability transition  MSCs  Mesenchymal stem cells  NGAL  Neutrophil gelatinase-associated lipocalin  MDM2  Murine double minute-2  MMP-2  Matrix metallopeptidase 2  mTOR  Mammalian target of rapamycin  PI3K  Phosphatidylinositol-3 kinase  PACAP  Pituitary adenylate cyclase activating polypeptide  RAAS  Renin–angiotensin–aldosterone system  RANTES  Regulated upon activation normal T-cell expressed and secreted  RIP1  Receptor-interacting protein 1  TNF-α  Tumor necrosis factor-alpha  TWEAK  TNF-like weak inducer of apoptosis  VDRA  Vitamin D receptor agonist  Acute kidney injury  Kidney protection  Kidney repair  Renoprotection  Ischemia–reperfusion  Nephrotoxicity  
DNAJB1 stabilizes MDM2 and contributes to cancer cell proliferation in a p53-dependent manner 期刊论文
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2014, 卷号: 1839, 期号: 1, 页码: 62-69
作者:  Qi, Min;  Zhang, Jianglin;  Zeng, Weiqi*;  Chen, Xiang
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/03
DNAJB1  MDM2  p53  p21  HSP70  
Association analysis between genetic variants of MDM2 gene and osteosarcoma susceptibility in Chinese 期刊论文
Endocrine Journal, 2013, 卷号: 60, 期号: 11, 页码: 1215-1220
作者:  He, Jinshan;  Wane, Jingcheng;  Wane, Daxin;  Dail, Shanhe;  Yvl, Tangyan
收藏  |  浏览/下载:6/0  |  提交时间:2019/12/03
Epigallocatechin gallate promotes p53 accumulation and activity via the inhibition of MDM2-mediated p53 ubiquitination in human lung cancer cells 期刊论文
Oncology Reports, 2013, 卷号: 29, 期号: 5, 页码: 1983-1990
作者:  Jin, Longyu;  Li, Cui;  Xu, Yan;  Wang, Li;  Liu, Jianxin
收藏  |  浏览/下载:17/0  |  提交时间:2019/12/03
Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth 期刊论文
Cancer Biology and Therapy, 2012, 卷号: 13, 期号: 10, 页码: 915-924
作者:  Zhang, Yiwei;  Zhang, Qi;  Zeng, Shelya X.;  Zhang, Yu;  Mayo, Lindsey D.
收藏  |  浏览/下载:5/0  |  提交时间:2019/12/03
The Tumor Suppressor UCHL1 Forms a Complex with p53/MDM2/ARF to Promote p53 Signaling and Is Frequently Silenced in Nasopharyngeal Carcinoma 期刊论文
Clinical Cancer Research, 2010, 卷号: 16, 期号: 11, 页码: 2949-2958
作者:  Lili Li;  Qian Tao;  Hongchuan Jin;  Andrew van Hasselt;  Fan Fong Poon
收藏  |  浏览/下载:10/0  |  提交时间:2019/12/03


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