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科研机构
山东大学 [2]
上海中医药大学 [2]
中国医学科学院 北京... [2]
上海药物研究所 [1]
上海大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [10]
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Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases
期刊论文
GLIA, 2019, 卷号: 67, 期号: 7, 页码: 1320-1332
作者:
Suo, Na
;
Guo, Yu-e
;
He, Bingqing
;
Gu, Haifeng
;
Xie, Xin
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2020/07/01
differentiation
ERK
MAPK
MEK inhibitor
myelin
oligodendrocyte
oligodendrocyte progenitor cell
remyelination
SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC
期刊论文
FRONTIERS IN ONCOLOGY, 2019, 卷号: 9
作者:
Yuan, Man
;
Xu, Lin-feng
;
Zhang, Juan
;
Kong, Si-yuan
;
Wu, Man
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
non-small-cell lung cancer
MEK and SRC inhibitor
trametinib
bosutinib
synergistic effect
A benzoxazole compound as a novel MEK inhibitor for the treatment of RAS/RAF mutant cancer
期刊论文
2019, 卷号: 145, 期号: 2, 页码: 586-596
作者:
Cheng, Ying
;
Wang, Xingkai
;
Xia, Xiangying
;
Zhang, Wei
;
Tian, Hongqi
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/01/03
benzoxazole compound
MEK inhibitor
RAF
RAS mutant cancer
synergism
high potency
Phosphodiesterase 4 Inhibitor Roflumilast Protects Rat Hippocampal Neurons from Sevoflurane Induced Injury via Modulation of MEK/ERK Signaling Pathway
期刊论文
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 卷号: 45, 期号: 6
作者:
Peng, Sheng
;
Yan, Hong-Zhu
;
Liu, Pei-Rong
;
Shi, Xiao-Wei
;
Liu, Chun-Liang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
Sevoflurane
Nerve damage
Roflumilast
CAMP
Phosphodiesterase 4 inhibitor (PDE-4i)
MEK/ERK pathway
Phosphodiesterase 4 Inhibitor Roflumilast Protects Rat Hippocampal Neurons from Sevoflurane Induced Injury via Modulation of MEK/ERK Signaling Pathway
期刊论文
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, 卷号: 45, 页码: 2329-2337
作者:
Peng Sheng[1]
;
Yan Hong-Zhu[2]
;
Liu Pei-Rong[3]
;
Shi Xiao-Wei[4]
;
Liu Chun-Liang[5]
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/04/24
CAMP
MEK/ERK pathway
Nerve damage
Phosphodiesterase 4 inhibitor (PDE-4i)
Roflumilast
Sevoflurane
The impact of P-glycoprotein and breast cancer resistance protein on the brain pharmacokinetics and pharmacodynamics of a panel of MEK inhibitors
期刊论文
INTERNATIONAL JOURNAL OF CANCER, 2018, 卷号: 142, 期号: 2, 页码: 381-391
作者:
de Gooijer, Mark C.
;
Zhang, Ping
;
Weijer, Ruud
;
Buil, Levi C. M.
;
Beijnen, Jos H.
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
glioma
pharmacokinetics
MEK inhibitor
ABC transporters
blood-brain-barrier
Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 47
作者:
Peng, Ling
;
Wang, Yina
;
Hong, Yun
;
Ye, Xianghua
;
Shi, Peng
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/05
BRAF inhibitor
MEK inhibitor
cuSCC
meta-analysis
MEK inhibitor can reverse the resistance to bevacizumab in A549 cells harboring Kirsten rat sarcoma oncogene homolog mutation
期刊论文
2016, 卷号: 7, 期号: 3, 页码: 279-287
作者:
Wang, Yuan
;
Yan, Ping
;
Liu, Zhentao
;
Yang, Xiaodan
;
Wang, Yaping
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Bevacizumab
connexin
MEK inhibitor
non-small-cell lung cancer
resistance
Up-regulation of urinary-type plasminogen activator correlates with high-risk papillary thyroid carcinoma with BRAFV600E mutation and its possible molecular mechanism
期刊论文
Pathology Research and Practice, 2014, 卷号: 210, 期号: 11, 页码: 733-738
作者:
Wakasa,T.
;
Li,Y.
;
Bai,Y.
;
Liu,Z.
;
Ozaki,T.
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/17
BRAF
ERK1/2
MEK inhibitor
Papillary thyroid cancer
Urinary-type plasminogen activator
The crossregulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor
期刊论文
JOURNAL OF MOLECULAR CELL BIOLOGY, 2012, 卷号: 4
-
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/10/26
KINASE KINASE-1/2 INHIBITOR
PHOSPHOINOSITIDE 3-KINASE-GAMMA
ADVANCED CANCERS
LUNG-CANCER
CELL LUNG
PHASE-II
RESISTANCE
ROBUSTNESS
ACTIVATION
MUTATIONS
systems biology
mathematical model
ERK pathway
PI3K pathway
MEK inhibitor
resistance
robustness
biochemical control analysis
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