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科研机构
上海药物研究所 [3]
四川大学 [3]
暨南大学 [2]
上海中医药大学 [2]
中国医学科学院 北京... [2]
山东大学 [1]
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期刊论文 [14]
会议论文 [2]
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2022 [1]
2019 [4]
2018 [4]
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Treatment outcomes and prognosis of patients with primary and acquired BRAF-mutated non-small cell lung cancer: A multicenter retrospective study
期刊论文
GENES CHROMOSOMES & CANCER, 2022
作者:
Wang, Wenxian
;
Gu, Xiaodong
;
Si, Jinfei
;
Pu, Xingxiang
;
Wang, Liping
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/05/16
BRAF mutation
immune checkpoint inhibitors
non-small cell lung cancer
PD-L1
targeted therapy
Combined mTOR/MEK inhibition prevents proliferation and induces apoptosis in NF2-mutant tumors
期刊论文
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2019, 卷号: 23, 期号: 13
作者:
Shi, W-Y
;
Lu, X-Y
;
Li, N.
;
Mao, F-J
;
Yang, X-Y
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
Neurofibromatosis type 2 gene
PI3K/mTOR pathway
Trametinib
Vistusertib
Proliferation
Apoptosis
SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC
期刊论文
FRONTIERS IN ONCOLOGY, 2019, 卷号: 9
作者:
Yuan, Man
;
Xu, Lin-feng
;
Zhang, Juan
;
Kong, Si-yuan
;
Wu, Man
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
non-small-cell lung cancer
MEK and SRC inhibitor
trametinib
bosutinib
synergistic effect
Zoledronic acid enhances the efficacy of the MEK inhibitor trametinib in KRAS mutant cancers
期刊论文
Cancer Letters, 2019, 卷号: Vol.442, 页码: 202-212
作者:
Xinyu Dai
;
Hongwei Xia
;
Sheng Zhou
;
Qiulin Tang
;
Feng Bi
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/02/28
RAS
MEK
Trametinib
Zoledronic
acid
Mevalonate
pathway
aberrantmodulationofribosomalproteins6phosphorylationconfersacquiredresistancetomapkpathwayinhibitorsinbrafmutantmelanoma
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 002, 页码: 268
作者:
Mingzhao Gao
;
Hongbin Wang
;
Xiangling Chen
;
Wenting Cao
;
Li Fu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
BRAF-mutant
melanoma
MAPK
pathway
inhibitors
acquired
resistance
P70S6K
RSK
rpS6
G1/G0
phase
arrest
mTOR
inhibitor
Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Gao, Ming-Zhao
;
Wang, Hong-Bin
;
Chen, Xiang-Ling
;
Cao, Wen-Ting
;
Fu, Li
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells
期刊论文
Journal of Experimental & Clinical Cancer Research, 2018, 卷号: Vol.37 No.1, 页码: 1-14
作者:
Sheng Zhou
;
Hongwei Xia
;
Huanji Xu
;
Qiulin Tang
;
Yongzhan Nie
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/02/25
Oestrogen-related
receptor
α
(ERRα)
Epidermal
growth
factor
(EGF)
Trametinib
Simvastatin
ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells
期刊论文
Journal of Experimental & Clinical Cancer Research, 2018, 卷号: Vol.37 No.1, 页码: 1-14
作者:
Sheng Zhou
;
Hongwei Xia
;
Huanji Xu
;
Qiulin Tang
;
Yongzhan Nie
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/02/25
Oestrogen-related
receptor
α
(ERRα)
Epidermal
growth
factor
(EGF)
Trametinib
Simvastatin
Acute Myeloid Leukaemia Therapy Relevant Drug-Drug Interaction (DDI) Due to the Pharmacokinetic Factors
期刊论文
LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 卷号: 37, 期号: 4, 页码: 804-807
作者:
Ji, Mu-Yuan
;
Yang, Xiao-Mei
;
Wei, Ruo-Ying
;
Zhang, Yuan-Yuan
;
Liu, Zhi-Juan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
acute myeloid leukaemia (AML)
drug-drug interaction
drug-metabolizing
enzymes
trametinib
AKT is critically involved in the antagonism of BRAF inhibitor sorafenib against dabrafenib in colorectal cancer cells harboring both wild-type and mutant (V600E) BRAF genes
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 卷号: 489, 期号: 1, 页码: 14-20
作者:
Wang, Hongbin
;
Quan, Haitian
;
Lou, Liguang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Antagonism
AKT
BRAF
Dabrafenib
Sorafenib
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