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大连化学物理研究所 [13]
上海药物研究所 [11]
西安交通大学 [7]
厦门大学 [5]
水生生物研究所 [4]
中国科学院大学 [4]
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期刊论文 [67]
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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
Expression profile of a novel glutathione S-transferase gene in the marine polychaete Perinereis aibuhitensis in short-term responses to phenanthrene, fluoranthene, and benzo[alpha]pyrene
期刊论文
MARINE POLLUTION BULLETIN, 2021, 卷号: 169, 页码: 6
作者:
Yuan, Xiutang
;
Zhao, Huan
;
Wang, Yinan
;
Wang, Lili
;
Li, Dongmei
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/10/21
Polychaete
PAH biotransformation
GST
Liaohe Estuary
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
Metabolic Profiling of Nuciferine in Vivo and in Vitro
期刊论文
Journal of Agricultural and Food Chemistry, 2020, 卷号: 68, 期号: 48, 页码: 14135-14147
作者:
Gao, Hua
;
Zhang, Lei
;
Zhu, An
;
Liu, Xiaoyan
;
Wang, Tianxia
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2022/02/17
Biomolecules
Enzymes
Mammals
Mass spectrometry
Metabolites
Broad spectrum
Drug formulations
High resolution mass spectrometry
Metabolic characteristics
Metabolic profiling
Molecular docking
Nelumbo nucifera
Recombinant enzymes
Pharmacologic characterization of fluzoparib, a novel poly(ADP-ribose) polymerase inhibitor undergoing clinical trials
期刊论文
CANCER SCIENCE, 2019, 卷号: 110, 期号: 3, 页码: 1064-1075
作者:
Wang, Lei
;
Yang, Changyong
;
Xie, Chengying
;
Jiang, Jiahua
;
Gao, Mingzhao
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
antitumor activity
fluzoparib
pharmacokinetics
poly(ADP-ribose) polymerase
toxicity
Estrogen sulfotransferase in the metabolism of estrogenic drugs and in the pathogenesis of diseases.
期刊论文
Expert opinion on drug metabolism & toxicology, 2019
作者:
Anne Caroline S Barbosa
;
Ye Feng
;
Chaohui Yu
;
Min Huang
;
Wen Xie
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/12/17
Diseases
Estrogen
Estrogen sulfotransferase
Estrogenic drugs
Metabolism
Phase II enzymes
Age-associated changes in GSH S-transferase gene/proteins in livers of rats
期刊论文
Redox report : communications in free radical research, 2018, 卷号: 23, 期号: 1, 页码: 213-218
作者:
Xu, Shangfu
;
Hou, Dongshun
;
Liu, Jie
;
Ji, Lili
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Druggable negative allosteric site of P2X3 receptors
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 19, 页码: 4939-4944
作者:
Wang, Jin
;
Wang, Yao
;
Cui, Wen-Wen
;
Huang, Yichen
;
Yang, Yang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
P2X3 receptors
allosteric inhibition
X-ray crystallography
AF-219
AF-353
Chemopreventive activity of sulforaphane
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2018, 卷号: 12
作者:
Jiang, Xin
;
Liu, Ye
;
Ma, Lixin
;
Ji, Rui
;
Qu, Yaqin
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2019/12/05
sulforaphane
tumor
chemoprevention
Phase I and Phase II drug-metabolizing enzymes
apoptosis
anti-inflammatory
cell cycle progression
epigenetics
Yinchenhao Decoction Ameliorates Alpha-Naphthylisothiocyanate Induced Intrahepatic Cholestasis in Rats by Regulating Phase II Metabolic Enzymes and Transporters
期刊论文
FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9
作者:
Yi, Ya-Xiong
;
Ding, Yue
;
Zhang, Yong
;
Ma, Ning-Hui
;
Shi, Feng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Yinchenhao Decoction
phase II metabolism
pharmacokinetics
cholestasis
bilirubin metabolism enzyme
metabolic transporter
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