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The reversal of anti-HER2 resistance in advanced HER2-positive breast cancer using apatinib: two cases reports and literature review
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2022
作者:
He, Libin
;
Shen, Xiabo
;
Liu, Yiyuan
;
Gao, Lu
;
Wu, Jiayi
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
Advanced human epidermal growth factor receptor 2-positive breast cancer (advanced HER2-positive breast cancer)
apatinib
case report
S3I-201 derivative incorporating naphthoquinone unit as effective STAT3 inhibitors: Design, synthesis and anti-gastric cancer evaluation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 卷号: 71
作者:
Li, Haobin
;
Cai, Maohua
;
Cao, Fei
;
Yu, Dehua
;
Yang, Jing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/12/22
STAT3 inhibitor
Quinone derivative
S3I-201
Anti -gastric cancer drug
Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
CDK9 inhibitors in cancer research
期刊论文
RSC MEDICINAL CHEMISTRY, 2022
作者:
Huang, Zhi
;
Wang, Tianqi
;
Wang, Cheng
;
Fan, Yan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2022/12/23
Inhibition of the deubiquitinating enzyme USP47 as a novel targeted therapy for hematologic malignancies expressing mutant EZH2
期刊论文
LEUKEMIA, 2022
作者:
Yang, Jing
;
Weisberg, Ellen L.
;
Qi, Shuang
;
Ni, Wei
;
Mei, Husheng
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2022/02/14
An overview of kinase downregulators and recent advances in discovery approaches
期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 卷号: 6
作者:
Wang, Beilei
;
Wu, Hong
;
Hu, Chen
;
Wang, Haizhen
;
Liu, Jing
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/25
TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery
期刊论文
DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455
作者:
Xiang, Shuang
;
Song, Shukai
;
Tang, Haotian
;
Smaill, Jeff B.
;
Wang, Aiqun
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/12/01
Antibiotic resistance
Computational biology
Databases
In silico tools
Structure-Based Virtual Screening and Identification of Potential Inhibitors of SARS-CoV-2 S-RBD and ACE2 Interaction
期刊论文
FRONTIERS IN CHEMISTRY, 2021, 卷号: 9, 页码: 12
作者:
Xiong, Jiacheng
;
Xiang, Yusen
;
Huang, Ziming
;
Liu, Xiaohong
;
Wang, Mengge
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2021/12/01
SARS-CoV-2
angiotensin-converting enzyme 2 (ACE2)
spike protein receptor-binding domain (S-RBD)
structure-based virtual screening
protein-protein interaction (PPI) inhibitors
Protein degradation technology: a strategic paradigm shift in drug discovery
期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2021, 卷号: 14
作者:
Li, Haobin
;
Dong, Jinyun
;
Cai, Maohua
;
Xu, Zhiyuan
;
Cheng, Xiang-Dong
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/11/01
Protein degradation
Degradation pathway
Degradation technology
PROTAC
Monomeric degraders
Design and Synthesis of Alkyl Phenols Inhibitors of Death Associated Apoptotic Protein Kinase 2 (DRAK2)
期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3204-3213
作者:
Zheng Zhang
;
Dai Chengqiu
;
Wu Honghong
;
Li Jingya
;
Nan Fajun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/11/04
death associated apoptotic protein kinase 2
diabetes
alkylphenols
inhibitors
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