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CORC

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Facing small and biased data dilemma in drug discovery with enhanced federated learning approaches 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2021, 页码: 11
作者:  Xiong, Zhaoping;  Cheng, Ziqiang;  Lin, Xinyuan;  Xu, Chi;  Liu, Xiaohong
收藏  |  浏览/下载：44/0  |  提交时间：2021/11/04
Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8644-8665
作者:  Kong, Qidi;  Pan, Wei;  Xu, Heng;  Xue, Yaru;  Guo, Bin
收藏  |  浏览/下载：38/0  |  提交时间：2021/08/17
Design and synthesis of novel desfluoroquinolone-aminopyrimidine hybrids as potent anti-MRSA agents with low hERG activity 期刊论文
BIOORGANIC CHEMISTRY, 2020, 卷号: 103, 页码: 10
作者:  Song, Runzhe;  Wang, Yue;  Wang, Minghui;  Gao, Ruixuan;  Yang, Teng
收藏  |  浏览/下载：20/0  |  提交时间：2020/12/24
Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8749-8760
作者:  Xiong, Zhaoping;  Wang, Dingyan;  Liu, Xiaohong;  Zhong, Feisheng;  Wan, Xiaozhe
收藏  |  浏览/下载：14/0  |  提交时间：2020/12/21
Development of Novel N-hydroxypyridone Derivatives as Potential Anti-Ischemic Stroke Agents 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 3, 页码: 1051-1067
作者:  Hu, Linghao;  Feng, Hongxuan;  Zhang, Hongguang;  Yu, Songda;  Zhao, Qinyuan
收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01
Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia 期刊论文
ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 6, 页码: 1216-1230
作者:  Wu, Chenglin;  Xi, Cong;  Tong, Junhua;  Zhao, Jing;  Jiang, Hualiang
收藏  |  浏览/下载：46/0  |  提交时间：2020/07/01
Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 18, 页码: 8642-8663
作者:  Hu, Jianping;  Tian, Chang-Qing;  Damaneh, Mohammadali Soleimani;  Li, Yanlian;  Cao, Danyan
收藏  |  浏览/下载：11/0  |  提交时间：2020/07/01
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 16, 页码: 7473-7488
作者:  Wang, Yulan;  Dai, Yang;  Wu, Xiaowei;  Li, Fei;  Liu, Bo
收藏  |  浏览/下载：18/0  |  提交时间：2020/07/01
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7264-7288
作者:  Dong, Xiaowu;  Zhan, Wenhu;  Zhao, Mengting;  Che, Jinxin;  Dai, Xiaoyang
收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01
Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino) pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 173, 页码: 44-62
作者:  Tong, Lexian;  Song, Pinrao;  Jiang, Kailong;  Xu, Lei;  Jin, Tingting
收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01

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