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大连化学物理研究所 [29]
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Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:
Liu, Lu
;
Li, Wei
;
Yang, Le
;
Guo, Zi-tao
;
Xue, Hao
收藏
  |  
浏览/下载:78/0
  |  
提交时间:2021/08/17
almonertinib
itraconazole
rifampicin
drug metabolism
drug interaction
CYP3A
P-gp
pharmacokinetics
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
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  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
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  |  
浏览/下载:67/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
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  |  
浏览/下载:68/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
电子垃圾拆解区复合污染水体中鱼的转录组特征与适应机制
学位论文
北京: 中国科学院生态环境研究中心, 2019
作者:
张望龙
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  |  
浏览/下载:19/0
  |  
提交时间:2020/07/29
电子垃圾,生态毒理,ahr,转录组,适应机制
electronic Waste, Ecotoxicology, Aryl Hydrocarbon Receptor, Transcriptome, Adaptation
Intravenous formulation of Panax notoginseng root extract: human pharmacokinetics of ginsenosides and potential for perpetrating drug interactions
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1351-1363
作者:
Pintusophon, Salisa
;
Niu, Wei
;
Duan, Xiao-na
;
Olaleye, Olajide E.
;
Huang, Yu-hong
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  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
ginsenoside
cytochrome P450 3A
organic anion-transporting polypeptide 1B3
herbal medicine-drug interactions
XueShuanTong
Panax notoginseng
Transcriptomic analysis of Anabas testudineus and its defensive mechanisms in response to persistent organic pollutants exposure
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 669, 页码: 621-630
作者:
Zhang, Wanglong
;
Xie, Heidi Qunhui
;
Li, Yunping
;
Jin, Tao
;
Li, Jiao
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  |  
浏览/下载:30/0
  |  
提交时间:2020/10/21
Pollution adaptation
POPs toxicology
Comparative transcriptomics
Gene family expansion
Aryl-hydrocarbon receptor
CYP3A
Comparative transcriptomic analysis provides insights into the response to the benzo(a)pyrene stress in aquatic firefly (Luciola leii)
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2019, 卷号: 661, 页码: 226-234
作者:
Zhang, Qi-Lin
;
Guo, Jun
;
Deng, Xian-Yu
;
Wang, Feng
;
Chen, Jun-Yuan (陈均远)
收藏
  |  
浏览/下载:97/0
  |  
提交时间:2019/05/22
Luciola Leii Larvae
Transcriptomics
Gene Expression
Benzo(a)Pyrene
Molecular Toxicology
Rna Sequencing
Genome-wide gene expression analysis reveals novel insights into the response to nitrite stress in gills of Branchiostoma belcheri
期刊论文
CHEMOSPHERE, 2019, 卷号: 218, 页码: 609-615
作者:
Zhang, Qi-Lin
;
Zhang, Guan-Ling
;
Xiong, Yan
;
Li, Hong-Wei
;
Guo, Jun
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/05/22
Branchiostoma Belcheri
Gene Expression Profiling
Gill
Nitrite
Molecular Toxicology
Rna-seq
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
作者:
Ma, Hong-Ping
;
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/06/20
bufotalin
cytochrome P450 3A (CYP3A)
hydroxylation
human liver microsomes (HLMs)
docking simulations
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