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科研机构
上海药物研究所 [14]
中南大学 [6]
暨南大学 [3]
中国医学科学院 北京... [3]
山东大学 [2]
厦门大学 [1]
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期刊论文 [32]
学位论文 [1]
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2019 [1]
2018 [4]
2017 [2]
2015 [5]
2014 [3]
2013 [5]
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Evaluation of inhibitory effects of flavonoids on breast cancer resistance protein (BCRP): From library screening to biological evaluation to structure-activity relationship
期刊论文
2019, 卷号: 61, 页码: 104642
作者:
Fan Xiaoqing
;
Bai Jie
;
Zhao Shengyu
;
Hu Minwan
;
Sun Yanhong
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/01/03
BCRP
Flavonoids
Inhibition
Molecular mechanism
Structure-activity relationships
Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter
期刊论文
Drug Metabolism and Disposition, 2018
作者:
Danyi Lu
;
Dong Dong
;
Qian Xie
;
Zhijie Li
;
Baojian Wu
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/31
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells
期刊论文
2018, 卷号: 296, 页码: 45
作者:
Li, Shishi[1]
;
Xu, Jinjin[1]
;
Yao, Zhihong[1,2]
;
Hu, Liufang[1,2]
;
Qin, Zifei[1,3]
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/13
Chemical inhibition and stable knock-down of efflux transporters leads to reduced glucuronidation of wushanicaritin in UGT1A1-overexpressing HeLa cells: the role of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) in the excretion of glucuronides
期刊论文
2018, 卷号: 9, 期号: 3, 页码: 1410
作者:
Qin, Zifei[1,2,3]
;
Li, Shishi[1]
;
Yao, Zhihong[1,2]
;
Hong, Xiaodan[1,4]
;
Wu, Baojian[1,2]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/06
Prenylflavonoid Isoxanthohumol Sensitizes MCF-7/ADR Cells to Doxorubicin Cytotoxicity via Acting as a Substrate of ABCB1
期刊论文
TOXINS, 2017, 卷号: 9, 期号: 7
作者:
Liu, Ming
;
Zhang, Weiyi
;
Zhang, Wei
;
Zhou, Xin
;
Li, Ming
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/08/19
isoxanthohumol
doxorubicin resistance
synergism
ABCB1
Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2017, 卷号: 203, 页码: 110-119
作者:
To, Kenneth K. W.
;
Wu, Xu
;
Yin, Chun
;
Chai, Stella
;
Yao, Sheng
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2019/01/08
ABCG2
Multidrug resistance
Marsdenia tenacissima
MRP1
P-glycoprotein
Polyoxypregnane compounds
Renal Tubular Secretion of Tanshinol: Molecular Mechanisms, Impact on Its Systemic Exposure, and Propensity for Dose-Related Nephrotoxicity and for Renal Herb-Drug Interactions
期刊论文
DRUG METABOLISM AND DISPOSITION, 2015, 卷号: 43, 期号: 5, 页码: 669-678
作者:
Jia, Weiwei
;
Du, Feifei
;
Liu, Xinwei
;
Jiang, Rongrong
;
Xu, Fang
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2019/01/08
Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb-drug interactions on OATP1B3
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2015, 卷号: 172, 期号: 4, 页码: 1059-1073
作者:
Jiang, Rongrong
;
Dong, Jiajia
;
Li, Xiuxue
;
Du, Feifei
;
Jia, Weiwei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites
期刊论文
2015, 卷号: 30, 期号: [db:dc_citation_issue], 页码: 425
作者:
Zhou, Xiaotong[1]
;
Wang, Shaoxiang[2]
;
Sun, Hua[1]
;
Wu, Baojian[1]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
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