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Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase
期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15
作者:
Li, Zhong
;
Zhang, Lilan
;
Xu, Kangwei
;
Jiang, Yuanyuan
;
Du, Jieke
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/13
Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir
期刊论文
SCIENCE, 2020, 卷号: 368, 期号: 6498, 页码: 1499-+
作者:
Yin, Wanchao
;
Mao, Chunyou
;
Luan, Xiaodong
;
Shen, Dan-Dan
;
Shen, Qingya
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  |  
浏览/下载:57/0
  |  
提交时间:2020/12/24
Structural analysis of a shrimp thymidylate synthase reveals species-specific interactions with dUMP and raltitrexed
期刊论文
JOURNAL OF OCEANOLOGY AND LIMNOLOGY, 2020, 页码: 9
作者:
Liu Changshui
;
Zang Kun
;
Li Shihao
;
Li Fuhua
;
Ma Qingiun
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  |  
浏览/下载:20/0
  |  
提交时间:2020/09/22
thymidylate synthase (TS)
closed conformation
deoxyuridine monophosphate (dUMP)
thymidine monophosphate (TMP)
raltitrexed
Litopenaeus vannamei
How Does Agonist and Antagonist Binding Lead to Different Conformational Ensemble Equilibria of the kappa-Opioid Receptor: Insight from Long-Time Gaussian Accelerated Molecular Dynamics Simulation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 3, 页码: 1575-1584
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Zhou, Shuangyan
;
Shi, Danfeng
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  |  
浏览/下载:57/0
  |  
提交时间:2019/11/10
kappa-opioid receptor
Gaussian accelerated molecular dynamics simulation
agonist
antagonist
conformational change
藻胆蛋白生物合成研究进展
期刊论文
科学通报, 2019, 卷号: 64, 期号: 01, 页码: 49-59
作者:
马丞博
;
秦松
;
李文军
;
葛保胜
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/08
藻胆蛋白
生物合成
体外重组
抗氧化
荧光
Structural basis for specific calcium binding by the polycystic-kidney-disease domain of Vibrio anguillarum protease Epp
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 505, 期号: 2, 页码: 471-477
作者:
Li, Peihai
;
Zang, Kun
;
Li, Yingjie
;
Liu, Changshui
;
Ma, Qingjun
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/05/15
Vibrio anguillarum
Polycystic-kidney-disease domain
Protease maturation
Ca2+-binding site
Protein stability
Structural basis for specific calcium binding by the polycystic-kidney-disease domain of Vibrio anguillarum protease Epp
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 卷号: 505, 期号: 2, 页码: 471-477
作者:
Li, Peihai
;
Zang, Kun
;
Li, Yingjie
;
Liu, Changshui
;
Ma, Qingjun
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2018/12/21
Vibrio anguillarum
Polycystic-kidney-disease domain
Protease maturation
Ca2+-binding site
Protein stability
Dimerization and Conformational Exchanges of the Receiver Domain of Response Regulator PhoB from Escherichia coli
期刊论文
JOURNAL OF PHYSICAL CHEMISTRY B, 2018, 卷号: 122, 期号: 22, 页码: 5749-5757
作者:
Liu, Yixiang
;
Li, Conggang
;
Liu, Maili
;
Jiang, Ling
;
Kou, Xinhui
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2018/08/15
Backbone resonance assignment of the response regulator protein PhoB(N) (F20D) from Escherichia coli
期刊论文
BIOMOLECULAR NMR ASSIGNMENTS, 2018, 卷号: 12, 期号: 1, 页码: 133-137
作者:
Kou, Xinhui
;
Liu, Xinghong
;
Liu, Yixiang
;
Li, Conggang
;
Liu, Maili
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2018/11/05
Chemical Shift Assignment
Nmr
Phob(n)(F20d)
Secondary Structure
Hsqc
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
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