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科研机构
上海药物研究所 [60]
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期刊论文 [60]
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2021 [6]
2020 [6]
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内容类型:期刊论文
专题:上海药物研究所
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Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2021, 卷号: 12, 页码: 14
作者:
Yang, Xinyu
;
Zhang, Xianfeng
;
Yang, Wei
;
Yu, Hang
;
He, Qianyan
收藏
  |  
浏览/下载:50/0
  |  
提交时间:2021/11/04
gut microbiota
adipose tissue dysfunction
molecular endocrinology
cardiovascular disease(s)
gut dysbiosis
Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18
作者:
Zhang, Ning
;
Tian, Yu-Nan
;
Zhou, Li-Na
;
Li, Meng-Zhu
;
Chen, Hua-Dong
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2021/05/24
Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 3, 页码: 1649-1669
作者:
Song, Zilan
;
Wang, Xiyuan
;
Zhang, Yan
;
Gu, Wangting
;
Shen, Ancheng
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  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Development of hedgehog pathway inhibitors by epigenetically targeting GLI through BET bromodomain for the treatment of medulloblastoma
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 2, 页码: 488-504
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Li, Yalei
;
Wang, Juan
;
Ding, Huaqian
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/05/24
Medulloblastoma
Hedgehog signaling
pathway
Drug resistance
GLI
BRD4
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1
作者:
Ning Zhang
;
Yu-Nan Tian
;
Li-Na Zhou
;
Meng-Zhu Li
;
Hua-Dong Chen
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/12/01
A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 409, 页码: 11
作者:
Li, Li
;
Ding, Chunyong
;
Zou, Chunpeng
;
Xiong, Zhi
;
Zhu, Weiwei
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2021/05/24
Salviadione derivative 15a
Diabetic nephropathy
Inflammation
Macrophage infiltration
Fibrosis
Nuclear factor-kappa B
Cytokines
Imidazole-fused benzothiadiazole-based red-emissive fluorescence probe for lysosomal pH imaging in living cells
期刊论文
TALANTA, 2020, 卷号: 217, 页码: 10
作者:
Li, Lingling
;
Li, Yang
;
Dang, Yijing
;
Chen, Tingting
;
Zhang, Ao
收藏
  |  
浏览/下载:116/0
  |  
提交时间:2020/12/24
Imidazole-fused benzothiadiazole
pH imaging
Lysosome
Fluorescence probe
Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses
期刊论文
ADVANCED MATERIALS, 2020, 页码: 11
作者:
Li, Jie
;
Wang, Hong
;
Wang, Yuqi
;
Gong, Xiang
;
Xu, Xiaoxuan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/12/24
anti-tumor immune responses
cancer immunotherapy
lipoproteins
oxaliplatin
tumor targeting
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
;
Niu, Ao
;
Li, Yuanqing
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
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