Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses

doi:10.1002/adma.202002380

	Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses
	Li, Jie 1,2,3; Wang, Hong 1,3; Wang, Yuqi 1; Gong, Xiang 1,3; Xu, Xiaoxuan 1,3; Sha, Xianyi 4; Zhang, Ao 1,2,3,5; Zhang, Zhiwen 1,3,6; Li, Yaping 1,3
刊名	ADVANCED MATERIALS
	2020-08-16
页码	11
关键词	anti-tumor immune responses cancer immunotherapy lipoproteins oxaliplatin tumor targeting
ISSN号	0935-9648
DOI	10.1002/adma.202002380
通讯作者	Zhang, Ao(ao6919zhang@sjtu.edu.cn) ; Zhang, Zhiwen(zwzhang0125@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要	The limited lymphocytes infiltration and immunosuppression in tumor are the major challenges of cancer immunotherapy. The use of immunogenic cell death (ICD)-inducing agents has potential to potentiate antitumor immune responses, but is tremendously hampered by the poor delivery efficiency. Herein, a tumor-activated size-enlargeable bioinspired lipoprotein of oxaliplatin (TA-OBL) is designed to access cancer cells and boost the ICD-induced antitumor immunity for synergizing immune-checkpoint blockades (ICBs)-mediated immunotherapy. TA-OBL is constructed by integrating a legumain-sensitive melittin conjugate for improving intratumoral permeation and cancer cell accessibility, a pH-sensitive phospholipid for triggering size-enlargement and drug release in intracellular acidic environments, a nitroreductase-sensitive hydrophobic oxaliplatin prodrug (N-OXP) for eliciting antitumor immunity into the bioinspired nano-sized lipoprotein system. TA-OBL treatment produced robust antitumor immune responses and its combination with ICBs demonstrates strong therapeutic benefits with delayed tumor growth and extended survival rate, making it a promising delivery nanoplatform to elicit antitumor immunity for cancer immunotherapy.
资助项目	Strategic Priority Research Program of CAS[XDA12050307] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS关键词	HETEROGENEITY ; METASTASIS
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000560595800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292390]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Ao; Zhang, Zhiwen; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuqian Rd, Beijing 100049, Peoples R China 4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 5.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China 6.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Li, Jie,Wang, Hong,Wang, Yuqi,et al. Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses[J]. ADVANCED MATERIALS,2020:11.
APA	Li, Jie.,Wang, Hong.,Wang, Yuqi.,Gong, Xiang.,Xu, Xiaoxuan.,...&Li, Yaping.(2020).Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses.ADVANCED MATERIALS,11.
MLA	Li, Jie,et al."Tumor-Activated Size-Enlargeable Bioinspired Lipoproteins Access Cancer Cells in Tumor to Elicit Anti-Tumor Immune Responses".ADVANCED MATERIALS (2020):11.