CORC

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CORC

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Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9
作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo
收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 32, 页码: 8
作者:  Wang, Xi;  Cheng, Xi;  Zhao, Lihua;  Wang, Yuzhe;  Ye, Chenyu
收藏  |  浏览/下载：25/0  |  提交时间：2021/11/04
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design 期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 15
作者:  Lu, Shaoyong;  He, Xinheng;  Yang, Zhao;  Chai, Zongtao;  Zhou, Shuhua
收藏  |  浏览/下载：35/0  |  提交时间：2021/11/04
Discovery of 5-Benzylidene-2-phenyl-1,3-dioxane-4,6-diones as Highly Potent and Selective SIRT1 Inhibitors 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 12, 期号: 3, 页码: 397-403
作者:  Li, Chunpu;  Hu, Sha-Sha;  Yang, Lisheng;  Wang, Min;  Long, Jian-Dong
收藏  |  浏览/下载：57/0  |  提交时间：2021/05/24
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines 期刊论文
FEBS JOURNAL, 2020, 页码: 18
作者:  Wang, Hui;  Meng, Qian;  Ding, Yiluan;  Xiong, Muya;  Zhu, Mengying
收藏  |  浏览/下载：84/0  |  提交时间：2020/12/24
Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1H-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5 期刊论文
MOLECULES, 2020, 卷号: 25, 期号: 12, 页码: 18
作者:  Han, Haozhen;  Li, Chunpu;  Li, Man;  Yang, Lisheng;  Zhao, Sen
收藏  |  浏览/下载：37/0  |  提交时间：2020/12/24
Common activation mechanism of class A GPCRs 期刊论文
ELIFE, 2019, 卷号: 8, 页码: 31
作者:  Zhou, Qingtong;  Yang, Dehua;  Wu, Meng;  Guo, Yu;  Guo, Wangjing
收藏  |  浏览/下载：66/0  |  提交时间：2020/07/01
Structural basis for ligand recognition of the human thromboxane A(2) receptor 期刊论文
NATURE CHEMICAL BIOLOGY, 2019, 卷号: 15, 期号: 1, 页码: 27-+
作者:  Fan, Hengxin;  Chen, Shuanghong;  Yuan, Xiaojing;  Han, Shuo;  Zhang, Hui
收藏  |  浏览/下载：89/0  |  提交时间：2019/01/08
Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 24, 页码: 9370-9387
作者:  Lei, Saifei;  Clydesdale, Lachlan;  Dai, Antao;  Cai, Xiaoqing;  Feng, Yang
收藏  |  浏览/下载：51/0  |  提交时间：2019/01/08
Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802 期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 4, 页码: 587-596
作者:  Zheng, Yue-ming;  Wang, Wan-fu;  Li, Yan-fen;  Yu, Yong;  Gao, Zhao-bing
收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08

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